Calas André
Institut des Maladies neurodégénératives, UMR CNRS 5293, Université de Bordeaux, 146 rue Léo-Saignat, 33000 Bordeaux, France.
Biol Aujourdhui. 2022;216(3-4):75-81. doi: 10.1051/jbio/2022024. Epub 2023 Feb 6.
This article relates the life, career and main scientific achievements of a pioneer in neuroendocrinology and French cell biology research, Mrs Andrée Tixier-Vidal, who passed away in December 2021. After her first works on hypophyseal-thyroid neuroendocrine axis, in birds then in mammals, Andrée Tixier-Vidal devoted herself then her group at the College of France to the histophysiological study of adenohypophysis and namely of prolactin (PRL) cells. Using in vitro models of organotypic cultures and cultures of GH3 cells, she described up to ultrastructural level the secretory process of PRL and its regulation by TRH. Furthermore, she extended her study to the TRH neurons themselves thanks to original models of in vitro cultures of hypothalamic neurons. Her fundamental and methodological achievements have largely contributed to major knowledge advances in cell biology of the secretion during the last century.
本文讲述了神经内分泌学和法国细胞生物学研究先驱安德烈·蒂西耶 - 维达尔夫人的生平、职业生涯及主要科学成就，她于2021年12月去世。在首次开展关于鸟类及随后哺乳动物的垂体 - 甲状腺神经内分泌轴的研究工作后，安德烈·蒂西耶 - 维达尔及其在法国高等师范学院的团队致力于腺垂体，尤其是催乳素（PRL）细胞的组织生理学研究。她利用器官型培养和GH3细胞培养的体外模型，在超微结构水平描述了PRL的分泌过程及其受促甲状腺激素释放激素（TRH）的调节。此外，借助下丘脑神经元体外培养的原始模型，她将研究扩展到TRH神经元本身。她在基础研究和方法学上的成就，在很大程度上推动了上个世纪分泌细胞生物学的重大知识进步。
