Development. 2023 Feb 15;150(3). doi: 10.1242/dev.201622. Epub 2023 Feb 6.
HAND2 is an important regulator of cardiac morphogenesis and is expressed throughout the heart. A new paper in Development dissects the gene regulatory networks downstream of HAND2 in the endocardium. To find out more about this research, we caught up with co-first author Beth Firulli and corresponding author Anthony (Tony) Firulli, Professor at Indiana Medical School. Co-first author Rajani George has left the Firulli lab and was not available for our interview.
HAND2是心脏形态发生的重要调节因子，在整个心脏中均有表达。《发育》杂志上发表的一篇新论文剖析了心内膜中HAND2下游的基因调控网络。为了深入了解这项研究，我们采访了共同第一作者贝丝·菲鲁利以及通讯作者安东尼（托尼）·菲鲁利，他是印第安纳医学院的教授。共同第一作者拉贾尼·乔治已离开菲鲁利实验室，无法接受我们的采访。
