偕肼基腙与氰胺的电化学环加成反应在取代的 5-氨基-1,2,4-三唑合成中的应用。
Electrochemical cycloaddition of hydrazones with cyanamide for the synthesis of substituted 5-amine-1,2,4-triazoles.
机构信息
Department of Chemical and Material Engineering, Quzhou College of Technology, No. 18 Jiangyuan Road, Quzhou 324002, Zhejiang, China.
Institute of Agricultural Resources and Environment, Ningxia Academy of Agriculture and ForestryScience, Yinchuan, P. R. China.
出版信息
Chem Commun (Camb). 2023 Feb 21;59(16):2303-2306. doi: 10.1039/d2cc06277a.
An eco-friendly and efficient electrochemical method for the synthesis of 5-amine-1,2,4-triazole derivatives has been developed by employing hydrazones or generation of hydrazones with cyanamide using KI as the catalyst and electrolyte. This strategy could be smoothly conducted with simple reaction conditions at room temperature without the addition of a chemical oxidant in an undivided cell, and cyanamide has been proven to be of great value in electrosynthesis.
开发了一种绿色环保且高效的电化学方法，用于合成 5-氨基-1,2,4-三唑衍生物，该方法采用腙或与氰氨生成腙，以碘化钾作为催化剂和电解质。该策略可以在室温下在简单的反应条件下顺利进行，无需在未分隔的电池中添加化学氧化剂，并且已经证明氰氨在电合成中具有很大的价值。
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