Dutta Subhabrata, Kayser Jacob, Waldvogel Siegfried R
Department of Electrosynthesis, Max-Planck-Institute for Chemical Energy Conversion, Stiftstraße 34-36, 45479 Mulheim an der Ruhr, Germany.
Department of Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55128 Mainz, Germany.
Org Lett. 2025 Jul 4;27(26):7053-7057. doi: 10.1021/acs.orglett.5c01968. Epub 2025 Jun 23.
A simple, straightforward, scalable, and sustainable electrochemical transformation of dihydrazones to alkynes via anodic oxidation has been developed. The protocol operates under galvanostatic conditions in a commercially available undivided cell utilizing reusable carbon-based electrodes. This methodology enables the efficient synthesis of a broad range of alkynes with moderate to excellent yield. The successful demonstration of gram-scale synthesis, along with a consistent electrode reusability profile, underlines the synthetic utility and preparative potential of the approach.
已开发出一种通过阳极氧化将双腙简单、直接、可扩展且可持续地电化学转化为炔烃的方法。该方案在恒电流条件下，在使用可重复使用的碳基电极的市售无隔膜电池中运行。这种方法能够以中等至优异的产率高效合成多种炔烃。克级规模合成的成功演示以及一致的电极可重复使用性表明了该方法的合成实用性和制备潜力。
