18 岁及以上抑郁障碍患者抗抑郁药治疗不依从相关因素的系统评价和荟萃分析方案。
Protocol for the systematic review and meta-analysis of factors associated with non-adherence to antidepressants in depressive disorders in those more than 18 years of age.
机构信息
Department of Psychiatry and Mental Health, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.
Chitwan Medical College, Bharatpur, Nepal.
出版信息
PLoS One. 2023 Feb 6;18(2):e0281366. doi: 10.1371/journal.pone.0281366. eCollection 2023.
OBJECTIVE
We have developed a protocol for the systematic review and meta-analysis of the factors associated with nonadherence to antidepressants in depressive patients more than 18 years of age.
METHODS
We will search articles with the databases PubMed- Medline, Scopus, Embase and PsychINFO. All the published literature reporting factors associated with nonadherence to antidepressants in depressive disorders in patients more than 18 years of age and fulfilling all the eligibility criteria till October 2022 will be included. The data will then be extracted and examined to be included in the systematic review. Finally, we will conduct meta-analysis for factors associated with non-adherence.
CONCLUSION
We will do extensive search on the proposed topic within the available literature and come up with a robust review of factors associated with nonadherence to antidepressants in patients age more than 18 years globally. The evidence generated would assist in designing interventions to address non-adherence in this group of patients leading to better productivity and quality of life.
目的
我们制定了一个方案，用于对 18 岁以上抑郁患者中与抗抑郁药治疗不依从相关的因素进行系统评价和荟萃分析。
方法
我们将在 PubMed-Medline、Scopus、Embase 和 PsychINFO 数据库中搜索文章。所有报告 18 岁以上抑郁障碍患者抗抑郁药治疗不依从相关因素且符合所有纳入标准的已发表文献，直至 2022 年 10 月，均将被纳入。然后将提取数据并进行检查，以纳入系统评价。最后，我们将对与不依从相关的因素进行荟萃分析。
结论
我们将在现有文献中对提出的主题进行广泛搜索，并对全球 18 岁以上患者抗抑郁药治疗不依从相关因素进行全面综述。生成的证据将有助于设计干预措施，以解决这组患者的不依从问题，从而提高他们的生产力和生活质量。
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