Foidart J M, Rorive G, Nusgens B
Biomedicine. 1978 Jul-Aug;28(4):215-9.
The synthesis and deposition of collagen and other proteins has been measured in the aorta of the rat by radiolabeling in short term organ culture. Under these conditions, the synthesis of collagen and other proteins is linear for at least five hours. Autoradiography demonstrates a labeling in all cell layers and protein deposition in the extracellular matrix. Hypertension was induced by renal ischemia using Goldblatt's technique. The synthesis and deposition of collagen was stimulated in aorta from the first week of hypertension and in pregnancy, and was even more increased in hypertensive pregnant animals. Reserpine suppresses the rise in blood pressure in operated animals and prevents these modifications.
通过短期器官培养中的放射性标记，已对大鼠主动脉中胶原蛋白和其他蛋白质的合成与沉积进行了测定。在这些条件下，胶原蛋白和其他蛋白质的合成至少在五个小时内呈线性。放射自显影显示所有细胞层均有标记，且细胞外基质中有蛋白质沉积。采用戈德布拉特技术通过肾缺血诱导高血压。从高血压第一周起，主动脉中胶原蛋白的合成与沉积在妊娠时受到刺激，在高血压妊娠动物中增加得更多。利血平可抑制手术动物血压升高并防止这些变化。
