Iurukova Ts, Georgiev P
Eksp Med Morfol. 1979;18(1):24-30.
The authors examined neosynthesis of fiber proteins (scleroproteins) in the aorta of rats with genetic hypertonia and with experimental atherosclerosis after application of 3H-proline and 3H-lysine and subsequent determination of radioactivity of collagenous and elastic in the aortic wall. There was a great increase in incorporation a labelled precursors of collagen and elastin in the aorta of hypertonic and atherosclerotic animals in comparison with the control rats-a manifestation of increased "de novo" synthesis of fiber proteins in rats with these arterial diseases. Furthermore the increased collagenosis dominated over that of elastogenesis. The irregularity in the activation of biosynthesis of both sclero-proteins in rats with hypertonia and atherosclerosis caused remodeling of macromolecular structure of the aretrial wall with a predominance of collagen over the remaining components of the connective tissue matrix. The resulting fibrosis of the arterial wall favoured the fixation of hypertonia and progression of atherosclerosis.
作者在给患有遗传性高血压和实验性动脉粥样硬化的大鼠注射³H - 脯氨酸和³H - 赖氨酸后，检测了主动脉中纤维蛋白（硬蛋白）的新合成情况，随后测定了主动脉壁中胶原蛋白和弹性蛋白的放射性。与对照大鼠相比，患有高血压和动脉粥样硬化的动物主动脉中胶原蛋白和弹性蛋白标记前体的掺入量大幅增加，这表明患有这些动脉疾病的大鼠中纤维蛋白的“从头”合成增加。此外，胶原生成增加超过了弹性生成。高血压和动脉粥样硬化大鼠中两种硬蛋白生物合成激活的不规则性导致主动脉壁大分子结构重塑，胶原蛋白在结缔组织基质的其余成分中占主导地位。由此产生的动脉壁纤维化有利于高血压的固定和动脉粥样硬化的进展。
