Vieira Filho S A, Nelson D L, Piló-Veloso D
Departamento de Bioquímica-Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte.
An Acad Bras Cienc. 1986 Dec;58(4):547-51.
Four new N-alkyl-2-mercapto-1-octylamine hydrochlorides were synthesized via the reaction of 1,2-epithio-octane with corresponding amines following by conversion to the hydrochlorides. The disulfides were obtained by oxidation of the respective thiols. Upon biological assay of the products for activity against infection by Schistosoma mansoni, only 2,2'-dithiobis(N-isobutyl-1-octylamine) exhibited activity.
通过1,2 - 硫代环氧辛烷与相应胺反应，随后转化为盐酸盐，合成了四种新的N - 烷基 - 2 - 巯基 - 1 - 辛胺盐酸盐。通过相应硫醇的氧化得到二硫化物。在对产物进行针对曼氏血吸虫感染的活性生物测定时，只有2,2'-二硫代双（N - 异丁基 - 1 - 辛胺）表现出活性。
