Fiorentino Teresa Vanessa, De Vito Francesca, Suraci Evelina, Marasco Raffaella, Hribal Marta Letizia, Luzza Francesco, Sesti Giorgio
Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Obesity (Silver Spring). 2023 Mar;31(3):724-731. doi: 10.1002/oby.23653. Epub 2023 Feb 6.
Prior evidence indicates that individuals with obesity have an accelerated intestinal glucose absorption. This cross-sectional study evaluated whether those with overweight or obesity display higher duodenal protein levels of the glucose carriers sodium-glucose cotransporter 1 (SGLT-1), glucose transporter 2 (GLUT-2), and glucose transporter 5 (GLUT-5).
SGLT-1, GLUT-2, and GLUT-5 protein levels were assessed on duodenal mucosa biopsies of 52 individuals without diabetes categorized on the basis of their BMI as lean, with overweight, or with obesity.
Individuals with overweight and obesity exhibited progressively increased duodenal protein levels of SGLT-1 and GLUT-5 as compared with the lean group. Conversely, no differences in duodenal GLUT-2 abundance were found among the three groups. Univariate analysis showed that SGLT-1 and GLUT-5 protein levels were positively correlated with BMI, waist circumference, 1-hour post-load glucose, fasting and post-load insulin, and insulin secretion and resistance levels. Furthermore, a positive relationship was detected between intestinal GLUT-5 levels and serum uric acid concentrations, a product of fructose metabolism known to be involved in the pathogenesis of obesity and its complications.
Individuals with overweight and obesity display enhanced duodenal SGLT-1 and GLUT-5 abundance, which correlates with increased postprandial glucose concentrations, insulin resistance, and hyperinsulinemia.
先前的证据表明，肥胖个体的肠道葡萄糖吸收加快。这项横断面研究评估了超重或肥胖个体的十二指肠中葡萄糖载体钠-葡萄糖协同转运蛋白1（SGLT-1）、葡萄糖转运蛋白2（GLUT-2）和葡萄糖转运蛋白5（GLUT-5）的蛋白水平是否更高。
对52名无糖尿病个体的十二指肠黏膜活检组织进行SGLT-1、GLUT-2和GLUT-5蛋白水平评估，这些个体根据体重指数分为消瘦、超重或肥胖。
与消瘦组相比，超重和肥胖个体的十二指肠SGLT-1和GLUT-5蛋白水平逐渐升高。相反，三组之间十二指肠GLUT-2丰度没有差异。单因素分析显示，SGLT-1和GLUT-5蛋白水平与体重指数、腰围、负荷后1小时血糖、空腹和负荷后胰岛素以及胰岛素分泌和抵抗水平呈正相关。此外，肠道GLUT-5水平与血清尿酸浓度之间存在正相关，血清尿酸是果糖代谢产物，已知参与肥胖及其并发症的发病机制。
超重和肥胖个体的十二指肠SGLT-1和GLUT-5丰度增加，这与餐后血糖浓度升高、胰岛素抵抗和高胰岛素血症相关。
