Cardiovascular Biomedicine Department, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano #1, Col. Sección XVI, Tlalpan, Mexico City 14080, Mexico.
Cardiology Laboratory at Translational Research Unit UNAM-INC, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano #1, Col. Sección XVI, Tlalpan, Mexico City 14080, Mexico.
Int J Mol Sci. 2023 Mar 23;24(7):6085. doi: 10.3390/ijms24076085.
Sugar transport through the plasma membrane is one of the most critical events in the cellular transport of nutrients; for example, glucose has a central role in cellular metabolism and homeostasis. The way sugars enter the cell involves complex systems. Diverse protein systems participate in the membrane traffic of the sugars from the extracellular side to the cytoplasmic side. This diversity makes the phenomenon highly regulated and modulated to satisfy the different needs of each cell line. The beautiful thing about this process is how evolutionary processes have diversified a single function: to move glucose into the cell. The deregulation of these entrance systems causes some diseases. Hence, it is necessary to study them and search for a way to correct the alterations and utilize these mechanisms to promote health. This review will highlight the various mechanisms for importing the valuable sugars needed to create cellular homeostasis and survival in all kinds of cells.
糖通过质膜的运输是营养物质细胞运输中最关键的事件之一;例如,葡萄糖在细胞代谢和内稳态中起着核心作用。糖进入细胞的方式涉及复杂的系统。多种蛋白系统参与了糖从细胞外到细胞质的膜转运。这种多样性使得这一现象受到高度调控和调节,以满足每个细胞系的不同需求。这个过程的美妙之处在于进化过程如何使单一功能多样化:将葡萄糖运入细胞。这些入口系统的失调会导致一些疾病。因此,有必要对其进行研究,并寻找一种方法来纠正这些改变,利用这些机制来促进健康。这篇综述将重点介绍各种机制,以进口在所有类型的细胞中创建细胞内稳态和生存所必需的有价值的糖。