世界卫生组织真菌优先病原体清单——改变游戏规则的因素。
The WHO fungal priority pathogens list as a game-changer.
机构信息
MRC Centre for Global Infectious Disease Analysis, Imperial College, London, UK.
Manchester Fungal Infection Group, The University of Manchester, Manchester, UK.
出版信息
Nat Rev Microbiol. 2023 Apr;21(4):211-212. doi: 10.1038/s41579-023-00861-x.
Abstract
Invasive fungal diseases are on the increase globally. The World Health Organization fungal priority pathogens list highlights fungi of critical or high importance to human health and provides pathways for action. The report calls for improved surveillance (diagnostics and antifungal resistance monitoring), research and innovation (implementation research) and public-health interventions.
摘要
全球侵袭性真菌病的发病率正在上升。世界卫生组织真菌优先病原体清单突出了对人类健康具有关键或高度重要性的真菌，并为采取行动提供了途径。该报告呼吁改善监测（诊断和抗真菌药物耐药性监测）、研究和创新（实施研究）以及公共卫生干预措施。
相似文献
1
The WHO fungal priority pathogens list as a game-changer.世界卫生组织真菌优先病原体清单——改变游戏规则的因素。
Nat Rev Microbiol. 2023 Apr;21(4):211-212. doi: 10.1038/s41579-023-00861-x.
2
Informing the World Health Organization Fungal Priority Pathogens List (WHO-FPPL): A collection of systematic reviews.为世界卫生组织真菌重点病原体清单（WHO-FPPL）提供信息：系统评价汇编。
Med Mycol. 2024 Jun 27;62(6). doi: 10.1093/mmy/myae046.
3
The WHO fungal priority pathogens list: a crucial reappraisal to review the prioritisation.世界卫生组织真菌优先病原体清单：重新评估以审查优先级的关键
Lancet Microbe. 2024 Jul;5(7):717-724. doi: 10.1016/S2666-5247(24)00042-9. Epub 2024 Apr 9.
4
Editorial: The World Health Organization (WHO) Fungal Priority Pathogens List in Response to Emerging Fungal Pathogens During the COVID-19 Pandemic.社论：世界卫生组织（WHO）真菌优先病原体清单，以应对 COVID-19 大流行期间出现的真菌病原体。
Med Sci Monit. 2022 Dec 1;28:e939088. doi: 10.12659/MSM.939088.
5
Pathogens of importance in lung disease-Implications of the WHO fungal priority pathogen list.肺部疾病中的重要病原体——世界卫生组织真菌重点病原体清单的影响
Respirology. 2024 Jan;29(1):21-23. doi: 10.1111/resp.14623. Epub 2023 Nov 13.
6
[Enlightenment of World Health Organization fungal priority pathogens list].[世界卫生组织真菌重点病原体清单的启示]
Zhonghua Liu Xing Bing Xue Za Zhi. 2023 Dec 10;44(12):1984-1987. doi: 10.3760/cma.j.cn112338-20230701-00410.
7
Inclusion of drugs on the World Health Organization's Essential Medicines List: A game-changer for obesity?将药物纳入世界卫生组织基本药物清单：对肥胖症而言是重大变革吗？
Diabetes Obes Metab. 2023 Aug;25(8):2423-2424. doi: 10.1111/dom.15114. Epub 2023 May 11.
8
WHO publish fungal priority pathogens list.世界卫生组织发布真菌重点病原体清单。
Lancet Microbe. 2023 Feb;4(2):e74. doi: 10.1016/S2666-5247(23)00003-4. Epub 2023 Jan 9.
9
Candida tropicalis-A systematic review to inform the World Health Organization of a fungal priority pathogens list.热带假丝酵母——为世界卫生组织提供真菌优先病原体清单的系统综述。
Med Mycol. 2024 Jun 27;62(6). doi: 10.1093/mmy/myae040.
10
[World Health Organization priority pathogen list and its enlightenment for research and development of medical countermeasures in China].[世界卫生组织重点病原体清单及其对我国医学应对措施研发的启示]
Zhonghua Liu Xing Bing Xue Za Zhi. 2025 Mar 10;46(3):519-526. doi: 10.3760/cma.j.cn112338-20241009-00621.
引用本文的文献
1
Role of the putative gene in normal germination of spores and virulence of the .假定基因在孢子正常萌发及该菌毒力中的作用。 （你提供的原文最后似乎不完整，这里是根据现有内容尽量完整翻译的）
Microb Cell. 2025 Aug 12;12:195-209. doi: 10.15698/mic2025.08.856. eCollection 2025.
2
Antifungal Drugs for the Treatment of Invasive Fungal Infections-A Limited Therapeutic Toolbox Facing Growing Resistances.用于治疗侵袭性真菌感染的抗真菌药物——面对不断增加的耐药性，一个有限的治疗手段库
Pharmaceuticals (Basel). 2025 Aug 19;18(8):1220. doi: 10.3390/ph18081220.
3
ER-mitochondrial crosstalk (ERMES) regulates cell wall composition in pathogenic fungi.内质网-线粒体相互作用（ERMES）调节致病真菌的细胞壁组成。
Arch Microbiol. 2025 Aug 27;207(10):237. doi: 10.1007/s00203-025-04448-3.
4
Overcoming Global Antifungal Challenges: Medical and Agricultural Aspects.应对全球抗真菌挑战：医学与农业层面
ACS Bio Med Chem Au. 2025 Jul 2;5(4):531-552. doi: 10.1021/acsbiomedchemau.5c00103. eCollection 2025 Aug 20.
5
Hidden Allies: Decoding the Core Endohyphal Bacteriome of Aspergillus fumigatus.隐藏的盟友：解读烟曲霉的核心内生真菌细菌群落
Environ Microbiol Rep. 2025 Aug;17(4):e70153. doi: 10.1111/1758-2229.70153.
6
Combination of isobavachalcone and amphotericin B has antifungal effect against and protects host tissue damage by inhibiting ferroptosis.异补骨脂查尔酮与两性霉素B联合使用具有抗真菌作用，并通过抑制铁死亡保护宿主组织损伤。
Virulence. 2025 Dec;16(1):2543981. doi: 10.1080/21505594.2025.2543981. Epub 2025 Aug 19.
7
Pathogenicity and virulence of Cryptococcus neoformans from an environmental perspective.从环境角度看新型隐球菌的致病性和毒力
Virulence. 2025 Dec;16(1):2547090. doi: 10.1080/21505594.2025.2547090. Epub 2025 Aug 14.
8
The Multifaceted Role of Regulatory T Cells in Sepsis: Mechanisms, Heterogeneity, and Pathogen-Tailored Therapies.调节性T细胞在脓毒症中的多方面作用：机制、异质性及病原体针对性疗法
Int J Mol Sci. 2025 Aug 1;26(15):7436. doi: 10.3390/ijms26157436.
9
Gene dosage and protein valency impact phase separation and fungal cell fate.基因剂量和蛋白质化合价影响相分离和真菌细胞命运。
PLoS Genet. 2025 Aug 8;21(8):e1011810. doi: 10.1371/journal.pgen.1011810. eCollection 2025 Aug.
10
The role of uncharacterized protein Taf1 in regulating ATP levels and virulence of Cryptococcus neoformans.未鉴定蛋白Taf1在调节新型隐球菌ATP水平和毒力中的作用。
BMC Microbiol. 2025 Aug 5;25(1):480. doi: 10.1186/s12866-025-04207-w.
本文引用的文献
1
Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?抗真菌药物在医学和农业中的双重用途：我们如何帮助防止人类病原体产生耐药性？
Drug Resist Updat. 2022 Dec;65:100885. doi: 10.1016/j.drup.2022.100885. Epub 2022 Oct 20.
2
Tackling the emerging threat of antifungal resistance to human health.应对抗真菌耐药性对人类健康构成的新威胁。
Nat Rev Microbiol. 2022 Sep;20(9):557-571. doi: 10.1038/s41579-022-00720-1. Epub 2022 Mar 29.
3
On the Emergence of Cryptococcus gattii in the Pacific Northwest: Ballast Tanks, Tsunamis, and Black Swans.论太平洋西北地区隐球菌的出现：压载水舱、海啸和黑天鹅。
mBio. 2019 Oct 1;10(5):e02193-19. doi: 10.1128/mBio.02193-19.
4
Global epidemiology of emerging Candida auris.新兴念珠菌全球流行病学。
Curr Opin Microbiol. 2019 Dec;52:84-89. doi: 10.1016/j.mib.2019.05.008. Epub 2019 Jul 3.
5
Virally-vectored vaccine candidates against white-nose syndrome induce anti-fungal immune response in little brown bats (Myotis lucifugus).针对白鼻综合征的病毒载体疫苗候选物可诱导小棕蝠（Myotis lucifugus）产生抗真菌免疫反应。
Sci Rep. 2019 May 1;9(1):6788. doi: 10.1038/s41598-019-43210-w.
6
Global and Multi-National Prevalence of Fungal Diseases-Estimate Precision.全球及多国真菌病患病率——估计精度
J Fungi (Basel). 2017 Oct 18;3(4):57. doi: 10.3390/jof3040057.
7
Cryptococcal meningitis: A neglected NTD?隐球菌性脑膜炎：一种被忽视的被忽视热带病？
PLoS Negl Trop Dis. 2017 Jun 29;11(6):e0005575. doi: 10.1371/journal.pntd.0005575. eCollection 2017 Jun.
8
Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis.HIV 相关隐球菌性脑膜炎的全球疾病负担：最新分析
Lancet Infect Dis. 2017 Aug;17(8):873-881. doi: 10.1016/S1473-3099(17)30243-8. Epub 2017 May 5.
Zotero 插件