Department of Biomedical and Clinical Sciences, DIBIC, Università degli Studi di Milano, Milan, Italy; III Division of Infectious Diseases, ASST Fatebenefratelli-Sacco, Luigi Sacco Hospital, Milan, Italy.
III Division of Infectious Diseases, ASST Fatebenefratelli-Sacco, Luigi Sacco Hospital, Milan, Italy.
Lancet Microbe. 2024 Jul;5(7):717-724. doi: 10.1016/S2666-5247(24)00042-9. Epub 2024 Apr 9.
In October, 2022, WHO published the first fungal priority pathogen list, which categorised 19 fungal entities into three priority groups (critical, high, and medium), for prioritisation of research efforts. The final ranking was determined via multiple criteria decision analysis, considering both research and development needs and perceived public health importance. In this Personal View, we discuss the positioning of the fungal pathogens, namely, Mucorales, Candida spp, Histoplasma spp, Coccidioides and Paracoccidioides spp, Fusarium spp, eumycetoma causative agents, Talaromyces marneffei, and Pneumocystis jirovecii, while expressing concerns about potential disparities between the WHO fungal priority pathogen list ranking and the actual disease burden associated with these pathogens. Finally, we propose a revised prioritisation list that also considers the regional disparities in the burden of fungal diseases.
2022 年 10 月，世卫组织发布了首份真菌优先病原体清单，将 19 种真菌实体分为三个优先组（关键、高和中），以优先考虑研究工作。最终排名是通过多标准决策分析确定的，同时考虑了研究和开发需求以及公众认为的重要性。在本个人观点中，我们讨论了真菌病原体的定位，即毛霉目、念珠菌属、组织胞浆菌属、球孢子菌属和副球孢子菌属、镰刀菌属、真丝真菌病病原体、马尔尼菲青霉和卡氏肺孢子虫，同时对世卫组织真菌优先病原体清单排名与这些病原体相关的实际疾病负担之间可能存在的差异表示关注。最后，我们提出了一个修订后的优先排序清单，同时也考虑了真菌感染疾病负担的区域差异。
