一项关于可控生活方式干预对炎症标志物影响的探索性分析——健康生活方式社区项目（队列2）。

Exploratory analysis of the effect of a controlled lifestyle intervention on inflammatory markers - the Healthy Lifestyle Community Programme (cohort 2).

作者信息

Koeder Christian, Anand Corinna, Husain Sarah, Kranz Ragna-Marie, Schoch Nora, Alzughayyar Dima, Bitterlich Norman, Hahn Andreas, Englert Heike

机构信息

Institute of Food Science and Human Nutrition, Leibniz University Hanover, Hanover, Germany.

Department of Nutrition, University of Applied Sciences Münster, Münster, Germany.

出版信息

BMC Nutr. 2023 Feb 6;9(1):25. doi: 10.1186/s40795-023-00684-2.

DOI:10.1186/s40795-023-00684-2

PMID:36747285

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9900566/

Abstract

BACKGROUND

Chronic low-grade inflammation is associated with an increased risk of chronic disease and mortality. The objective of the study was to test the effect of a healthy lifestyle intervention on biomarkers of inflammation (among other risk markers).

METHODS

We conducted a non-randomized controlled trial with mostly middle-aged and elderly participants from the general population in rural northwest Germany (intervention: n = 114; control: n = 87). The intervention consisted of a 1-year lifestyle programme focusing on diet (largely plant-based; strongest emphasis), physical activity, stress management, and social support. High-sensitivity C-reactive protein (hs-CRP) was assessed at baseline, 10 weeks, 6 months, and 1 year. Homocysteine (Hcy) was assessed at baseline, 10 weeks, and 1 year. Adiponectin (Apn) was assessed at baseline and 10 weeks. An exploratory analysis of these inflammatory markers assessing the between-group differences with ANCOVA was conducted.

RESULTS

The 1-year trajectory of hs-CRP was significantly lower in the intervention group compared to control (between-group difference: -0.8 (95% CI -1.2, -0.3) mg/l; p = 0.001; adjusted for baseline). The 1-year trajectory of Hcy was non-significantly higher in the intervention compared to control (between-group difference: 0.2 (95% CI -0.3, 0.7) µmol/l; p = 0.439; adjusted for baseline). From baseline to 10 weeks, Apn decreased significantly more in the intervention group compared to control (between-group difference: -1.6 (95% CI -2.7, -0.5) µg/ml; p = 0.004; adjusted for baseline).

CONCLUSIONS

Our study shows that healthy lifestyle changes can lower hs-CRP and Apn levels and are unlikely to significantly affect Hcy levels within 1 year.

TRIAL REGISTRATION

German Clinical Trials Register (DRKS; reference: DRKS00018775 , registered 12 Sept 2019; retrospectively registered; www.drks.de ).

摘要

背景

慢性低度炎症与慢性病风险及死亡率增加相关。本研究的目的是测试健康生活方式干预对炎症生物标志物（以及其他风险标志物）的影响。

方法

我们对德国西北部农村地区的普通人群中主要为中年和老年参与者进行了一项非随机对照试验（干预组：n = 114；对照组：n = 87）。干预包括一项为期1年的生活方式计划，重点关注饮食（主要是植物性饮食；最为强调）、体育活动、压力管理和社会支持。在基线、10周、6个月和1年时评估高敏C反应蛋白（hs-CRP）。在基线、10周和1年时评估同型半胱氨酸（Hcy）。在基线和10周时评估脂联素（Apn）。对这些炎症标志物进行探索性分析，采用协方差分析评估组间差异。

结果

与对照组相比，干预组hs-CRP的1年轨迹显著更低（组间差异：-0.8（95%CI -1.2，-0.3）mg/l；p = 0.001；根据基线进行调整）。与对照组相比，干预组Hcy的1年轨迹略高但无显著差异（组间差异：0.2（95%CI -0.3，0.7）µmol/l；p = 0.439；根据基线进行调整）。从基线到10周，与对照组相比，干预组Apn下降幅度显著更大（组间差异：-1.6（95%CI -2.7，-0.5）µg/ml；p = 0.004；根据基线进行调整）。