The structural gene for lecithin:cholesterol acyl transferase (LCAT) maps to 16q22.

作者信息

Azoulay M, Henry I, Tata F, Weil D, Grzeschik K H, Chaves M E, McIntyre N, Williamson R, Humphries S E, Junien C

机构信息

Groupe de Recherches de Biologie Prénatale, INSERM U 73, Paris, France.

出版信息

Ann Hum Genet. 1987 May;51(2):129-36. doi: 10.1111/j.1469-1809.1987.tb01054.x.

We have used a cDNA clone for human lecithin:cholesterol acyl transferase (LCAT) and Southern blotting techniques to identify the human LCAT gene in DNA from a series of rodent X human somatic cell hybrids. Our results are compatible with the location of the gene on human chromosome 16, and this has been confirmed using in situ hybridization of the LCAT cDNA to human metaphase chromosomes. These results confirm the earlier studies on LCAT-deficient patients, indicating that the structural gene for LCAT is on human chromosome 16q22.