Sun Shuhui, Ma Shuai, Cai Yusheng, Wang Si, Ren Jie, Yang Yuanhan, Ping Jiale, Wang Xuebao, Zhang Yiyuan, Yan Haoteng, Li Wei, Esteban Concepcion Rodriguez, Yu Yan, Liu Feifei, Izpisua Belmonte Juan Carlos, Zhang Weiqi, Qu Jing, Liu Guang-Hui
State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Institute for Stem Cell and Regeneration, CAS, Beijing 100101, China.
Innovation (Camb). 2023 Jan 5;4(1):100380. doi: 10.1016/j.xinn.2023.100380. eCollection 2023 Jan 30.
Exercise benefits the whole organism, yet, how tissues across the body orchestrally respond to exercise remains enigmatic. Here, in young and old mice, with or without exercise, and exposed to infectious injury, we characterized the phenotypic and molecular adaptations to a 12-month exercise across 14 tissues/organs at single-cell resolution. Overall, exercise protects tissues from infectious injury, although more effectively in young animals, and benefits aged individuals in terms of inflammaging suppression and tissue rejuvenation, with structural improvement in the central nervous system and systemic vasculature being the most prominent. In vascular endothelial cells, we found that readjusting the rhythmic machinery via the core circadian clock protein BMAL1 delayed senescence and facilitated recovery from infectious damage, recapitulating the beneficial effects of exercise. Our study underscores the effect of exercise in reconstituting the youthful circadian clock network and provides a foundation for further investigating the interplay between exercise, aging, and immune challenges across the whole organism.
运动有益于整个机体，然而，身体各组织如何协同应对运动仍不清楚。在此，我们以单细胞分辨率对年轻和年老小鼠在有或没有运动的情况下，以及暴露于感染性损伤时，14个组织/器官在12个月运动过程中的表型和分子适应性进行了表征。总体而言，运动可保护组织免受感染性损伤，尽管在年轻动物中更有效，并且在抑制炎症衰老和组织年轻化方面有益于老年个体，其中中枢神经系统和全身血管系统的结构改善最为显著。在血管内皮细胞中，我们发现通过核心生物钟蛋白BMAL1重新调整节律机制可延缓衰老并促进从感染性损伤中恢复，概括了运动的有益效果。我们的研究强调了运动在重建年轻生物钟网络方面的作用，并为进一步研究运动、衰老和整个机体免疫挑战之间的相互作用提供了基础。
