• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Multi-omics decodes exercise-induced geroprotection: betaine unlocks aging delay via TBK1 inhibition.

作者信息

Li Yang, Guo Liang, Wang Ru

机构信息

Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.

School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, 200438, China.

出版信息

Sci China Life Sci. 2025 Jun 27. doi: 10.1007/s11427-025-3000-5.

DOI:10.1007/s11427-025-3000-5
PMID:40588595
Abstract
摘要

相似文献

1
Multi-omics decodes exercise-induced geroprotection: betaine unlocks aging delay via TBK1 inhibition.多组学解码运动诱导的老年保护:甜菜碱通过抑制TBK1延缓衰老。
Sci China Life Sci. 2025 Jun 27. doi: 10.1007/s11427-025-3000-5.
2
Systematic profiling reveals betaine as an exercise mimetic for geroprotection.系统分析表明,甜菜碱是一种模拟运动的老年保护剂。
Cell. 2025 Jun 25. doi: 10.1016/j.cell.2025.06.001.
3
Biomarkers of geroprotection and cardiovascular health: An overview of omics studies and established clinical biomarkers in the context of diet.老年保护和心血管健康的生物标志物:饮食背景下的组学研究及既定临床生物标志物概述
Crit Rev Food Sci Nutr. 2023;63(15):2426-2446. doi: 10.1080/10408398.2021.1975638. Epub 2021 Oct 14.
4
Betaine delays age-related muscle loss by mitigating Mss51-induced impairment in mitochondrial respiration via Yin Yang1.甜菜碱通过阴阳1减轻Mss51诱导的线粒体呼吸损伤,从而延缓与年龄相关的肌肉流失。
J Cachexia Sarcopenia Muscle. 2024 Oct;15(5):2104-2117. doi: 10.1002/jcsm.13558. Epub 2024 Aug 26.
5
Network integration of thermal proteome profiling with multi-omics data decodes PARP inhibition.热蛋白质组 profiling 与多组学数据的网络整合解码 PARP 抑制。
Mol Syst Biol. 2024 Apr;20(4):458-474. doi: 10.1038/s44320-024-00025-w. Epub 2024 Mar 7.
6
Spatial transformation of multi-omics data unlocks novel insights into cancer biology.多组学数据的空间转换揭示了癌症生物学的新见解。
Elife. 2023 Sep 5;12:RP87133. doi: 10.7554/eLife.87133.
7
Parkin overexpression alleviates cardiac aging through facilitating K63-polyubiquitination of TBK1 to facilitate mitophagy.帕金蛋白的过表达通过促进TBK1的K63-多聚泛素化以促进线粒体自噬来减轻心脏衰老。
Biochim Biophys Acta Mol Basis Dis. 2021 Jan 1;1867(1):165997. doi: 10.1016/j.bbadis.2020.165997. Epub 2020 Oct 22.
8
Betaine Delayed Muscle Loss by Attenuating Samtor Complex Inhibition for mTORC1 Signaling Via Increasing SAM Level.甜菜碱通过增加 SAM 水平来减弱 Samtor 复合物对 mTORC1 信号的抑制作用,从而延缓肌肉损失。
Mol Nutr Food Res. 2021 Aug;65(15):e2100157. doi: 10.1002/mnfr.202100157. Epub 2021 Jun 25.
9
Exercise orchestrates systemic metabolic and neuroimmune homeostasis via the brain-muscle-liver axis to slow down aging and neurodegeneration: a narrative review.运动通过脑-肌肉-肝脏轴协调全身代谢和神经免疫稳态,以减缓衰老和神经退行性变:一项叙述性综述。
Eur J Med Res. 2025 Jun 12;30(1):475. doi: 10.1186/s40001-025-02751-9.
10
Attitudes towards geroprotection: measuring willingness, from lifestyle changes to drug use.对老年保护的态度:衡量从生活方式改变到药物使用的意愿。
Front Aging. 2024 Nov 5;5:1440661. doi: 10.3389/fragi.2024.1440661. eCollection 2024.

本文引用的文献

1
Global insights into aging: a multidisciplinary approach to understanding and addressing age-related challenges.对衰老的全球洞察:一种理解和应对与年龄相关挑战的多学科方法。
Life Med. 2024 Aug 20;3(3):lnae029. doi: 10.1093/lifemedi/lnae029. eCollection 2024 Jun.
2
Understanding the variation in exercise responses to guide personalized physical activity prescriptions.了解运动反应的变化,以指导个性化的体育活动处方。
Cell Metab. 2024 Apr 2;36(4):702-724. doi: 10.1016/j.cmet.2023.12.025. Epub 2024 Jan 22.
3
A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body.
运动诱导的全身抗炎和老年保护作用的单细胞转录组图谱。
Innovation (Camb). 2023 Jan 5;4(1):100380. doi: 10.1016/j.xinn.2023.100380. eCollection 2023 Jan 30.
4
Exercise plasma boosts memory and dampens brain inflammation via clusterin.运动能使血浆中的斑联蛋白含量升高,从而增强记忆力并抑制大脑炎症。
Nature. 2021 Dec;600(7889):494-499. doi: 10.1038/s41586-021-04183-x. Epub 2021 Dec 8.
5
Beneficial Effects of Betaine: A Comprehensive Review.甜菜碱的有益作用:综述
Biology (Basel). 2021 May 22;10(6):456. doi: 10.3390/biology10060456.
6
Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise.分子转导物理活动联盟(MoTrPAC):描绘运动的动态响应。
Cell. 2020 Jun 25;181(7):1464-1474. doi: 10.1016/j.cell.2020.06.004.
7
TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging.TBK1 抑制发育过程中和衰老过程中 RIPK1 驱动的细胞凋亡和炎症。
Cell. 2018 Sep 6;174(6):1477-1491.e19. doi: 10.1016/j.cell.2018.07.041. Epub 2018 Aug 23.
8
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.先天免疫衔接蛋白 MAVS、STING 和 TRIF 的磷酸化诱导 IRF3 的激活。
Science. 2015 Mar 13;347(6227):aaa2630. doi: 10.1126/science.aaa2630. Epub 2015 Jan 29.