Li Ke, Hu Sihan, Chen Hao
Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, PR China.
The Key Laboratory of the Jiangsu Higher Education Institutions for Nucleic Acid & Cell Fate Regulation, Yangzhou, PR China.
Bone Res. 2025 Jul 7;13(1):68. doi: 10.1038/s41413-025-00448-7.
Cellular senescence and its senescence-associated secretory phenotype (SASP) represent a pivotal role in the development of skeletal diseases. Targeted elimination or rejuvenation of senescent cells has shown potential as a therapeutic strategy to reverse age-related skeletal senescence and promote bone regeneration. Meanwhile, other age-related mechanisms, involving altered cellular functions, impaired intercellular crosstalk, disturbed tissue microenvironment, and decreased regenerative capacity, synergistically contribute to the pathogenesis. In this review, we outline the cellular senescence and other age-related mechanisms in developing skeletal diseases, including osteoporosis, intervertebral disc degeneration, osteoarthritis, rheumatoid arthritis, bone tumors and ankylosing spondylitis, with the aim of comprehensively understanding their detrimental effects on the aged skeleton and screening the potential targets for anti-aging therapy within the skeletal system.
细胞衰老及其衰老相关分泌表型（SASP）在骨骼疾病的发展中起着关键作用。靶向清除或恢复衰老细胞已显示出作为一种治疗策略的潜力，可逆转与年龄相关的骨骼衰老并促进骨再生。同时，其他与年龄相关的机制，包括细胞功能改变、细胞间串扰受损、组织微环境紊乱和再生能力下降，协同促成发病机制。在本综述中，我们概述了骨骼疾病发生过程中的细胞衰老及其他与年龄相关的机制，包括骨质疏松症、椎间盘退变、骨关节炎、类风湿性关节炎、骨肿瘤和强直性脊柱炎，旨在全面了解它们对老年骨骼的有害影响，并筛选骨骼系统内抗衰老治疗的潜在靶点。
