Mehta Kahini, Pines Adam, Adebimpe Azeez, Larsen Bart, Bassett Dani S, Calkins Monica E, Baller Erica, Gell Martin, Patrick Lauren M, Gur Raquel E, Gur Ruben C, Roalf David R, Romer Daniel, Wolf Daniel H, Kable Joseph W, Satterthwaite Theodore D
Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA.
bioRxiv. 2023 Jan 26:2023.01.25.525577. doi: 10.1101/2023.01.25.525577.
Delay discounting is a measure of impulsive choice relevant in adolescence as it predicts many real-life outcomes, including substance use disorders, obesity, and academic achievement. However, the functional networks underlying individual differences in delay discounting during youth remain incompletely described. Here we investigate the association between multivariate patterns of functional connectivity and individual differences in impulsive choice in a large sample of youth. A total of 293 youth (9-23 years) completed a delay discounting task and underwent resting-state fMRI at 3T. A connectome-wide analysis using multivariate distance-based matrix regression was used to examine whole-brain relationships between delay discounting and functional connectivity was then performed. These analyses revealed that individual differences in delay discounting were associated with patterns of connectivity emanating from the left dorsal prefrontal cortex, a hub of the default mode network. Delay discounting was associated with greater functional connectivity between the dorsal prefrontal cortex and other parts of the default mode network, and reduced connectivity with regions in the dorsal and ventral attention networks. These results suggest that delay discounting in youth is associated with individual differences in relationships both within the default mode network and between the default mode and networks involved in attentional and cognitive control.
延迟折扣是一种与青少年冲动选择相关的测量方法，因为它能预测许多现实生活中的结果，包括物质使用障碍、肥胖和学业成绩。然而，青少年时期延迟折扣个体差异背后的功能网络仍未得到充分描述。在此，我们在一大群青少年样本中研究功能连接的多变量模式与冲动选择个体差异之间的关联。共有293名青少年（9至23岁）完成了一项延迟折扣任务，并在3T条件下接受了静息态功能磁共振成像。使用基于多变量距离的矩阵回归进行全脑连接组分析，以检查延迟折扣与功能连接之间的全脑关系。这些分析表明，延迟折扣的个体差异与源自左背外侧前额叶皮层（默认模式网络的一个枢纽）的连接模式有关。延迟折扣与背外侧前额叶皮层与默认模式网络其他部分之间更强的功能连接相关，而与背侧和腹侧注意网络区域的连接减少。这些结果表明，青少年的延迟折扣与默认模式网络内部以及默认模式网络与参与注意力和认知控制的网络之间关系的个体差异有关。
