McKean Rachel, Wolf Jennifer, Wong Ting Ting, Yin Yong Mei, Kanis Margaux J
Division of Gynecologic Oncology, New York Presbyterian Brooklyn Methodist Hospital, 506 6 Street, Brooklyn, NY 11215, United States.
Division of Gynecologic Oncology, State University of New York Downstate Health Sciences University, 450 Clarkson Avenue, Brooklyn, NY 11203, United States.
Gynecol Oncol Rep. 2023 Jan 24;45:101142. doi: 10.1016/j.gore.2023.101142. eCollection 2023 Feb.
Patients with human immunodeficiency virus (HIV) are at increased risk for developing other gynecologic conditions, including herpes simplex virus (HSV) and vulvar intraepithelial neoplasia (VIN)/carcinoma. We describe the case of a woman with a history of microinvasive vulvar squamous cell carcinoma who presented with hypertrophic ulcerated vulvar and -anal masses concerning for malignancy. This case highlights the need to maintain a high index of suspicion for malignancy and herpes simplex virus, even with negative polymerase chain reaction (PCR) test, as well as the difficulty of treating this often-resistant lesion.
感染人类免疫缺陷病毒（HIV）的患者患其他妇科疾病的风险增加，包括单纯疱疹病毒（HSV）和外阴上皮内瘤变（VIN）/癌。我们描述了一名有微浸润性外阴鳞状细胞癌病史的女性病例，该患者出现了肥厚性溃疡外阴和肛门肿物，怀疑为恶性肿瘤。该病例强调，即使聚合酶链反应（PCR）检测结果为阴性，也需要对恶性肿瘤和单纯疱疹病毒保持高度怀疑，同时也凸显了治疗这种常常具有耐药性的病变的困难。
