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颞叶癫痫中的海马神经元丢失:与幼儿期惊厥的相关性。

Hippocampal neuron loss in temporal lobe epilepsy: correlation with early childhood convulsions.

作者信息

Sagar H J, Oxbury J M

机构信息

Department of Neurology, Radcliffe Infirmary, Oxford, England.

出版信息

Ann Neurol. 1987 Sep;22(3):334-40. doi: 10.1002/ana.410220309.

DOI:10.1002/ana.410220309
PMID:3674798
Abstract

Hippocampal neuron densities in three areas (H1 zone, end folium, and dentate gyrus) were counted in each of 32 temporal lobectomy excision specimens using the technique of Mouritzen Dam. The association between severe neuronal loss in all three areas and early childhood convulsions that were prolonged and/or lateralized was highly significant. Lesser degrees of neuron loss in H1 and/or end folium were common and were not associated with early childhood convulsions, but were most often found in older patients with a particularly long history of epilepsy.

摘要

使用穆里岑·达姆技术,对32个颞叶切除术切除标本中的三个区域(H1区、终叶和齿状回)的海马神经元密度进行了计数。所有三个区域严重神经元丢失与延长和/或侧化的幼儿惊厥之间的关联非常显著。H1区和/或终叶中较轻程度的神经元丢失很常见,且与幼儿惊厥无关,但最常出现在癫痫病史特别长的老年患者中。

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