Zhu Lujian, Luo Shengnan, Zhu Yin, Tang Shiyue, Li Chenge, Jin Xiaozhi, Wu Faling, Jiang Huimian, Wu Lina, Xu Yejin
Department of Infectious Diseases, Jinhua Municipal Central Hospital, Jinhua, People's Republic of China.
Department of Infectious Diseases, Taizhou Enze Medical Center (Group), Enze Hospital, Taizhou, People's Republic of China.
J Inflamm Res. 2023 Jan 31;16:381-389. doi: 10.2147/JIR.S385977. eCollection 2023.
Ferroptosis is a recently identified iron-dependent form of intracellular lipid peroxide accumulation-mediated cell death. Different from other types of cell death mechanisms, it exhibits distinct biological and morphological features characterized by the loss of lipid peroxidase repair activity caused by glutathione peroxidase 4, the presence of redox-active iron, and the oxidation of phospholipids-containing polyunsaturated fatty acids. In recent years, studies have shown that ferroptosis plays a key role in various liver diseases such as alcoholic liver injury, non-alcoholic steatohepatitis, liver cirrhosis, and liver cancer. However, the mechanism of ferroptosis and its regulation on chronic liver disease are controversial among different types of cells in the liver. Herein, we summarize the current studies on mechanism of ferroptosis in chronic liver disease, aiming to outline the blueprint of ferroptosis as an effective option for chronic liver disease therapy.
铁死亡是一种最近被发现的、由细胞内脂质过氧化物积累介导的铁依赖性细胞死亡形式。与其他类型的细胞死亡机制不同，它表现出独特的生物学和形态学特征，其特征包括谷胱甘肽过氧化物酶4导致脂质过氧化物修复活性丧失、存在氧化还原活性铁以及含多不饱和脂肪酸的磷脂氧化。近年来，研究表明铁死亡在多种肝脏疾病如酒精性肝损伤、非酒精性脂肪性肝炎、肝硬化和肝癌中起关键作用。然而，在肝脏不同类型的细胞中，铁死亡的机制及其对慢性肝病的调节存在争议。在此，我们总结了目前关于慢性肝病中铁死亡机制的研究，旨在勾勒出铁死亡作为慢性肝病治疗有效选择的蓝图。
