Ghalib Syed Muhammad Sarosh, Hashmi Faizeaab, Zuberi Umra Fatima, Aqeel Sana
Department of Zoology, Aligarh Muslim University, Aligarh, India.
Section of Parasitology, Department of Zoology, Aligarh Muslim University, Aligarh, India.
Int Microbiol. 2025 Feb 21. doi: 10.1007/s10123-025-00645-8.
Amoebiasis and its extraintestinal manifestation amoebic liver abscess (ALA) is an endemic disease in tropical and subtropical countries. However, no meta-analysis on the prevalence, associated risk factors, and clinical markers has been performed. This study aims to bridge this research gap. Based on our inclusion criteria, 18 studies were selected for analysis. Using the "meta" package in RStudio, forest plots, regression analysis, and funnel plots were used to represent the proportional meta-analysis, significance of the correlation, and quality and publication bias of the included studies, respectively. A high prevalence of ALA (67%, p = 1.762 × 10) was noted in cases of liver abscess. ALA was significantly more prevalent in males (86%, p = 2.25 × 10), individuals with poor socioeconomic conditions (75%, p = 0.02496), history of alcohol consumption (63%, p = 1.421 × 10), and diabetic comorbidity (35%, p = 0.01169). There was a significant correlation with abdominal pain (91%, p = 1.286 × 10), infected right lobe (81%, p = 0.002), fever (73%, p = 2.567 × 10), hepatomegaly (69%, p = 1.223 × 10), anemia (69%, p = 1.223 × 10), and jaundice (11%, p = 0005258) in the affected individuals. We conclude that the above-stated risk factors and clinical markers are significantly associated with ALA and suggest that medical professionals in endemic regions must attribute liver abscess to be etiologically amoebic and correlate the disease manifestation with the risk factors and clinical markers. Further, research is needed to better understand disease manifestation.
阿米巴病及其肠外表现阿米巴肝脓肿（ALA）是热带和亚热带国家的一种地方病。然而，尚未对其患病率、相关危险因素和临床标志物进行荟萃分析。本研究旨在填补这一研究空白。根据我们的纳入标准，选择了18项研究进行分析。使用RStudio中的“meta”包，森林图、回归分析和漏斗图分别用于表示纳入研究的比例荟萃分析、相关性的显著性以及质量和发表偏倚。在肝脓肿病例中发现ALA的患病率很高（67%，p = 1.762×10）。ALA在男性（86%，p = 2.25×10）、社会经济状况较差的个体（75%，p = 0.02496）、有饮酒史的个体（63%，p = 1.421×10）和合并糖尿病的个体（35%，p = 0.01169）中更为普遍。在受影响的个体中，与腹痛（91%，p = 1.286×10）、右叶感染（81%，p = 0.002）、发热（73%，p = 2.567×10）、肝肿大（69%，p = 1.223×10）、贫血（69%，p = 1.223×10）和黄疸（11%，p = 0.005258）存在显著相关性。我们得出结论，上述危险因素和临床标志物与ALA显著相关，并建议流行地区的医学专业人员必须将肝脓肿归因于阿米巴病因，并将疾病表现与危险因素和临床标志物联系起来。此外，需要进一步研究以更好地了解疾病表现。
