• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

肿瘤驻留记忆 T 细胞在食管鳞癌转移性淋巴结中的预后相关性。

Prognostic relevance of tumor-resident memory T cells in metastatic lymph nodes of esophageal squamous cell carcinoma.

机构信息

Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

出版信息

Cancer Sci. 2023 May;114(5):1846-1858. doi: 10.1111/cas.15750. Epub 2023 Feb 21.

DOI:10.1111/cas.15750
PMID:36748311
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10154829/
Abstract

Tumor-resident memory T (T ) cells in primary tumors are reportedly associated with a favorable prognosis in several malignancies. However, the behaviors and functions of T cells in regional lymph nodes (LNs) of esophageal cancer remain poorly understood. The aim of this study was to elucidate the effects of T cells in regional LNs of esophageal cancer on clinicopathological findings and prognosis. Specimens of esophageal cancer and primary metastatic LNs (recurrent nerve LNs) were obtained from 84 patients who underwent radical esophagectomy between 2011 and 2017. We performed immunohistochemistry to enumerate and analyze T cells, and used flow cytometry to investigate the function of T cells. T cells were observed in both metastatic LNs and primary tumors. T cell-rich specimens exhibited reduced lymphatic invasion and LN metastasis and prolonged survival compared with T cell-poor specimens. T cells in metastatic LNs were more significantly associated with enhanced survival than T cells in primary tumors. T cells expressed high levels of granzyme B as a cytotoxicity marker. Our results suggested that high T cell infiltration in metastatic LNs improves survival even though LN metastasis is commonly associated with poor prognosis. T cells possibly contribute to antitumor immunity in regional LNs.

摘要

肿瘤驻留记忆 T(T)细胞在几种恶性肿瘤中与预后良好有关。然而，食管癌区域淋巴结(LNs)中 T 细胞的行为和功能仍知之甚少。本研究旨在阐明食管癌区域 LNs 中 T 细胞对临床病理发现和预后的影响。收集了 2011 年至 2017 年间接受根治性食管切除术的 84 例食管癌患者的食管癌和原发性转移性 LNs(神经 LN)标本。我们进行了免疫组织化学计数和分析 T 细胞，并使用流式细胞术研究 T 细胞的功能。转移性 LNs 和原发性肿瘤中均观察到 T 细胞。与 T 细胞稀少的标本相比，T 细胞丰富的标本表现出淋巴管浸润和 LN 转移减少，生存时间延长。转移性 LNs 中的 T 细胞与生存时间的改善更显著相关，而原发性肿瘤中的 T 细胞则不然。T 细胞表达高水平的颗粒酶 B 作为细胞毒性标志物。我们的结果表明，转移性 LNs 中高 T 细胞浸润可改善生存，尽管 LN 转移通常与预后不良相关。T 细胞可能有助于区域 LNs 中的抗肿瘤免疫。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67c2/10154829/3394c9c2000d/CAS-114-1846-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67c2/10154829/9311c048546d/CAS-114-1846-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67c2/10154829/2c721d85611e/CAS-114-1846-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67c2/10154829/c7dd95082f6f/CAS-114-1846-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67c2/10154829/24b348f61581/CAS-114-1846-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67c2/10154829/2c7f5718c407/CAS-114-1846-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67c2/10154829/3394c9c2000d/CAS-114-1846-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67c2/10154829/9311c048546d/CAS-114-1846-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67c2/10154829/2c721d85611e/CAS-114-1846-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67c2/10154829/c7dd95082f6f/CAS-114-1846-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67c2/10154829/24b348f61581/CAS-114-1846-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67c2/10154829/2c7f5718c407/CAS-114-1846-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67c2/10154829/3394c9c2000d/CAS-114-1846-g007.jpg

相似文献

1
Prognostic relevance of tumor-resident memory T cells in metastatic lymph nodes of esophageal squamous cell carcinoma.肿瘤驻留记忆 T 细胞在食管鳞癌转移性淋巴结中的预后相关性。
Cancer Sci. 2023 May;114(5):1846-1858. doi: 10.1111/cas.15750. Epub 2023 Feb 21.
2
Cervical lymph node metastasis classified as regional nodal staging in thoracic esophageal squamous cell carcinoma after radical esophagectomy and three-field lymph node dissection.在根治性食管切除术和三野淋巴结清扫术后，颈淋巴结转移在胸段食管鳞状细胞癌中被归类为区域淋巴结分期。
BMC Surg. 2014 Dec 19;14:110. doi: 10.1186/1471-2482-14-110.
3
Characteristics and clinical significance of recurrent laryngeal nerve lymph node metastasis in esophageal squamous cell carcinoma.食管鳞状细胞癌喉返神经淋巴结转移的特征及临床意义
J BUON. 2017 Nov-Dec;22(6):1533-1539.
4
Clinical Impact of Metastatic Lymph Node Size on Therapeutic Effect and Prognosis in Patients with Esophageal Squamous Cell Carcinoma Who Underwent Preoperative Chemotherapy Followed by Esophagectomy.术前化疗联合食管癌切除术治疗后转移性淋巴结大小对食管鳞癌患者治疗效果及预后的临床影响。
Ann Surg Oncol. 2023 Jul;30(7):4193-4202. doi: 10.1245/s10434-023-13393-8. Epub 2023 Apr 3.
5
Lymph node ratio-based staging system for esophageal squamous cell carcinoma.基于淋巴结比率的食管鳞状细胞癌分期系统
World J Gastroenterol. 2015 Jun 28;21(24):7514-21. doi: 10.3748/wjg.v21.i24.7514.
6
Usefulness of Biopsy Specimens for Evaluating CD103 Tumor-resident Memory T Cells in Esophageal Cancer.评估食管癌中 CD103 肿瘤驻留记忆 T 细胞的活检标本的实用性。
Anticancer Res. 2023 Nov;43(11):4823-4832. doi: 10.21873/anticanres.16679.
7
The Number of Harvested LNs Is an Independent Prognostic Factor in Lymph Node Metastasis-negative Patients Who Received Curative Esophagectomy.清扫的淋巴结数目是接受根治性食管切除术且淋巴结转移阴性患者的独立预后因素。
In Vivo. 2020 Jul-Aug;34(4):2021-2027. doi: 10.21873/invivo.12001.
8
Prognostic value of subcarinal lymph node metastasis in patients with esophageal squamous cell carcinoma.食管鳞状细胞癌患者隆突下淋巴结转移的预后价值
Asian Pac J Cancer Prev. 2013;14(5):3183-6. doi: 10.7314/apjcp.2013.14.5.3183.
9
[Influence of number of removed lymph nodes on the TNM staging and survival in advanced esophageal carcinoma].[切除淋巴结数量对晚期食管癌TNM分期及生存的影响]
Zhonghua Zhong Liu Za Zhi. 2007 Aug;29(8):604-8.
10
Effect of the number of lymph nodes sampled on postoperative survival of lymph node-negative esophageal cancer.取样淋巴结数量对淋巴结阴性食管癌患者术后生存的影响。
Cancer. 2008 Mar 15;112(6):1239-46. doi: 10.1002/cncr.23309.

引用本文的文献

1
Harnessing biomarkers to guide immunotherapy in esophageal cancer: toward precision oncology.利用生物标志物指导食管癌免疫治疗：迈向精准肿瘤学。
Clin Transl Oncol. 2025 Sep 6. doi: 10.1007/s12094-025-04051-4.
2
Tissue-Resident Memory T Cells in Cancer Metastasis Control.癌症转移控制中的组织驻留记忆性T细胞
Cells. 2025 Aug 21;14(16):1297. doi: 10.3390/cells14161297.
3
Tissue-resident memory T cells in diseases and therapeutic strategies.疾病中的组织驻留记忆T细胞及治疗策略

本文引用的文献

1
The evolving role of tissue-resident memory T cells in infections and cancer.组织驻留记忆 T 细胞在感染和癌症中的不断演变的作用。
Sci Adv. 2022 Aug 19;8(33):eabo5871. doi: 10.1126/sciadv.abo5871. Epub 2022 Aug 17.
2
Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells.卵巢癌的免疫原性由祖细胞组织驻留记忆 T 细胞的一个狭窄亚群控制。
Cancer Cell. 2022 May 9;40(5):545-557.e13. doi: 10.1016/j.ccell.2022.03.008. Epub 2022 Apr 14.
3
The cell-surface 5'-nucleotidase CD73 defines a functional T memory cell subset that declines with age.
MedComm (2020). 2025 Jan 12;6(1):e70053. doi: 10.1002/mco2.70053. eCollection 2025 Jan.
4
The emerging role of effector functions exerted by tissue-resident memory T cells.组织驻留记忆T细胞发挥的效应功能的新作用。
Oxf Open Immunol. 2024 Jun 14;5(1):iqae006. doi: 10.1093/oxfimm/iqae006. eCollection 2024.
5
Tissue-Resident Memory T Cells in Gastrointestinal Cancers: Prognostic Significance and Therapeutic Implications.胃肠道癌症中的组织驻留记忆T细胞：预后意义与治疗启示
Biomedicines. 2024 Jun 17;12(6):1342. doi: 10.3390/biomedicines12061342.
6
Significance of CD103 tissue-resident memory T cells for predicting the effectiveness of immune checkpoint inhibitors in esophageal cancer.CD103 组织驻留记忆 T 细胞对预测食管癌免疫检查点抑制剂疗效的意义。
BMC Cancer. 2023 Oct 20;23(1):1011. doi: 10.1186/s12885-023-11438-5.
细胞表面 5'-核苷酸酶 CD73 定义了一个具有功能性的 T 记忆细胞亚群，该亚群随着年龄的增长而减少。
Cell Rep. 2021 Nov 9;37(6):109981. doi: 10.1016/j.celrep.2021.109981.
4
Tertiary lymphoid structures show infiltration of effective tumor-resident T cells in gastric cancer.三级淋巴结构显示胃癌中有浸润的有效肿瘤驻留 T 细胞。
Cancer Sci. 2021 May;112(5):1746-1757. doi: 10.1111/cas.14888. Epub 2021 Apr 1.
5
Prognostic Significance of CD4+ and CD8+ Tumor-Infiltrating Lymphocytes in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis.头颈部鳞状细胞癌中CD4 +和CD8 +肿瘤浸润淋巴细胞的预后意义：一项荟萃分析
Cancers (Basel). 2021 Feb 13;13(4):781. doi: 10.3390/cancers13040781.
6
Intratumoral CD103CD4 T cell infiltration defines immunoevasive contexture and poor clinical outcomes in gastric cancer patients.肿瘤内CD103⁺CD4⁺ T细胞浸润定义了胃癌患者的免疫逃逸结构和不良临床结局。
Oncoimmunology. 2020 Nov 22;9(1):1844402. doi: 10.1080/2162402X.2020.1844402.
7
Memory CD8 T cell responses to cancer.癌症的记忆 CD8 T 细胞反应。
Semin Immunol. 2020 Jun;49:101435. doi: 10.1016/j.smim.2020.101435. Epub 2020 Nov 30.
8
Tumor-Infiltrating Lymphocytes and Their Prognostic Value in Cutaneous Melanoma.肿瘤浸润淋巴细胞及其在皮肤黑色素瘤中的预后价值。
Front Immunol. 2020 Sep 10;11:2105. doi: 10.3389/fimmu.2020.02105. eCollection 2020.
9
Characterization of CD103 CD8 tissue-resident T cells in esophageal squamous cell carcinoma: may be tumor reactive and resurrected by anti-PD-1 blockade.CD103+CD8+ 食管鳞状细胞癌组织驻留 T 细胞的特征：可能是肿瘤反应性的，并可被抗 PD-1 阻断剂复活。
Cancer Immunol Immunother. 2020 Aug;69(8):1493-1504. doi: 10.1007/s00262-020-02562-3. Epub 2020 Apr 13.
10
A conserved dendritic-cell regulatory program limits antitumour immunity.一个保守的树突状细胞调控程序限制了抗肿瘤免疫。
Nature. 2020 Apr;580(7802):257-262. doi: 10.1038/s41586-020-2134-y. Epub 2020 Mar 25.