格雷夫斯眼病中 Th17 细胞及相关细胞因子的研究进展。
Research progress in Th17 cells and the relevant cytokines in Graves ophthalmopathy.
机构信息
Graduate Student of 2021, Henan University of Chinese Medicine, Zhengzhou 450046.
Second Ward of Endocrinology Department, First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450099.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022 Dec 28;47(12):1748-1753. doi: 10.11817/j.issn.1672-7347.2022.220205.
Graves' ophthalmopathy is the most common clinical orbital disease, and T helper (Th) cells play an important role in the development of Graves' ophthalmopathy. Th17 cells are a major subpopulation of Th cells and abnormally highly expressed in patients with Graves' ophthalmopathy. Th17 cells and the related cytokines interleukin (IL)-17A, IL-21 and IL-23 are involved in regulating the inflammatory response, fibrosis and adipogenesis. Th17 cells are unstable and exhibit a degree of plasticity, and they can differentiate into IL-17A and interferon (IFN)-γ dual-producing Th17.1 cells, which exacerbate the pathogenicity of Th17 cells. In addition, Th17 cells and the relevant factors are strongly associated with disease activity and severity in Graves' ophthalmopathy.
格雷夫斯眼病是最常见的临床眼眶疾病，辅助性 T 细胞（Th）在格雷夫斯眼病的发生发展中发挥重要作用。Th17 细胞是 Th 细胞的主要亚群之一，在格雷夫斯眼病患者中异常高表达。Th17 细胞及其相关细胞因子白细胞介素（IL）-17A、IL-21 和 IL-23 参与调节炎症反应、纤维化和脂肪生成。Th17 细胞不稳定，表现出一定程度的可塑性，可分化为同时产生白细胞介素（IL）-17A 和干扰素（IFN）-γ的 Th17.1 细胞，从而加重 Th17 细胞的致病性。此外，Th17 细胞及其相关因子与格雷夫斯眼病的疾病活动度和严重程度密切相关。
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