眼内透镜表面改性以预防后囊膜混浊的跨学科医学和工程研究进展。
Advances in interdisciplinary medical and engineering research of intraocular lens surface modifications to prevent posterior capsule opacification.
机构信息
Eye Center of Xiangya Hospital, Central South University; Hunan Key Laboratory of Ophthalmology, Changsha 410008, China.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022 Dec 28;47(12):1754-1762. doi: 10.11817/j.issn.1672-7347.2022.220277.
Abstract
Posterior capsule opacification (PCO), a common complication after cataract surgery, impacts a patient's long-term visual quality to various degrees. Although a neodymium:yttrium aluminum garnet (Nd:YAG) laser posterior capsulotomy is a very effective treatment, it may lead to a serial of complications. Accordingly, the search for simple, safe, and effective methods to prevent PCO has received widespread attention. Various researchers are committed to the interdisciplinary collaboration between medicine and engineering fields, such as functionalizing the surface of the intraocular lens (IOL) via supercritical fluid impregnation, coating the surface of the IOL, high-concentration drug immersion, and application of a drug delivery system, to effectively reduce the incidence and severity of PCO.
摘要
后发性白内障（PCO）是白内障手术后的一种常见并发症，会对患者的长期视觉质量产生不同程度的影响。虽然钕:钇铝石榴石（Nd:YAG）激光后囊切开术是一种非常有效的治疗方法，但它可能会导致一系列并发症。因此，寻找简单、安全、有效的方法来预防 PCO 已经引起了广泛关注。许多研究人员致力于医学和工程领域之间的交叉学科合作，例如通过超临界流体浸渍对人工晶状体（IOL）的表面进行功能化、IOL 表面涂层、高浓度药物浸泡以及药物输送系统的应用，以有效降低 PCO 的发生率和严重程度。
相似文献
1
Advances in interdisciplinary medical and engineering research of intraocular lens surface modifications to prevent posterior capsule opacification.眼内透镜表面改性以预防后囊膜混浊的跨学科医学和工程研究进展。
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022 Dec 28;47(12):1754-1762. doi: 10.11817/j.issn.1672-7347.2022.220277.
2
Intraocular lens optic edge design for the prevention of posterior capsule opacification after cataract surgery.白内障手术后预防后囊膜混浊的人工晶状体光学边缘设计。
Cochrane Database Syst Rev. 2021 Aug 16;8(8):CD012516. doi: 10.1002/14651858.CD012516.pub2.
3
Rotating the Intraocular Lens to Prevent Posterior Capsular Opacification in Cataract Surgeries.旋转人工晶状体以预防白内障手术后后囊膜混浊。
J Vis Exp. 2023 Jul 7(197). doi: 10.3791/65419.
4
Eradication of posterior capsule opacification: documentation of a marked decrease in Nd:YAG laser posterior capsulotomy rates noted in an analysis of 5416 pseudophakic human eyes obtained postmortem.后囊膜混浊的消除：在对5416只死后获得的人工晶状体眼进行分析时发现，钕:钇铝石榴石激光后囊切开术的发生率显著降低。
Ophthalmology. 2001 Mar;108(3):505-18. doi: 10.1016/s0161-6420(00)00589-3.
5
Comparison of the Incidence of Nd:YAG Laser Capsulotomy Based on the Type of Intraocular Lens.基于人工晶状体类型的 Nd:YAG 激光后囊切开术发生率比较。
Medicina (Kaunas). 2023 Dec 14;59(12):2173. doi: 10.3390/medicina59122173.
6
Economic considerations related to choice of intraocular lens (IOL) and posterior capsule opacification frequency - a comparison of three different IOLs.与人工晶状体（IOL）选择和后囊混浊频率相关的经济考虑因素——三种不同 IOL 的比较。
Acta Ophthalmol. 2014 Mar;92(2):179-83. doi: 10.1111/aos.12026. Epub 2012 Dec 31.
7
5 year incidence of YAG capsulotomy and PCO after cataract surgery with single-piece monofocal intraocular lenses: a real-world evidence study of 20,763 eyes.5 年 YAG 后囊切开术和白内障术后后发性白内障的发生率：20763 只眼的真实世界证据研究。
Eye (Lond). 2020 May;34(5):960-968. doi: 10.1038/s41433-019-0630-9. Epub 2019 Oct 15.
8
Evaluation of neodymium:yttrium-aluminum-garnet capsulotomies in eyes implanted with AcrySof intraocular lenses.植入AcrySof人工晶状体的眼中钕:钇铝石榴石晶状体囊切开术的评估
Ophthalmology. 2002 Aug;109(8):1421-6. doi: 10.1016/s0161-6420(02)01116-8.
9
Incidence of primary peripheral posterior capsular opacification after cataract surgery and posterior capsular opacification in the patients implanted with foldable intraocular lenses.白内障手术后原发性周边后囊膜混浊的发生率以及植入可折叠人工晶状体患者的后囊膜混浊情况。
Nepal J Ophthalmol. 2017 Jul;9(18):149-155. doi: 10.3126/nepjoph.v9i2.19259.
10
Update on fixation of rigid and foldable posterior chamber intraocular lenses. Part II: Choosing the correct haptic fixation and intraocular lens design to help eradicate posterior capsule opacification.硬性和可折叠后房型人工晶状体固定的最新进展。第二部分：选择正确的袢固定方式和人工晶状体设计以帮助消除后囊混浊。
Ophthalmology. 1999 May;106(5):891-900. doi: 10.1016/S0161-6420(99)00506-0.
引用本文的文献
1
Identification of spontaneous age-related cataract in .识别……中的自发性年龄相关性白内障
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2024 Apr 28;49(4):553-561. doi: 10.11817/j.issn.1672-7347.2024.230534.
本文引用的文献
1
Role of fibronectin and IOL surface modification in IOL: Lens capsule interactions.纤维连接蛋白和人工晶状体表面修饰在人工晶状体与晶状体囊袋相互作用中的作用。
Exp Eye Res. 2022 Aug;221:109135. doi: 10.1016/j.exer.2022.109135. Epub 2022 Jun 1.
2
Correction: Surface modification of intraocular lenses with hyaluronic acid and lysozyme for the prevention of endophthalmitis and posterior capsule opacification.更正：用透明质酸和溶菌酶对人工晶状体进行表面改性以预防眼内炎和后囊膜混浊。
RSC Adv. 2022 Mar 7;12(12):7403-7404. doi: 10.1039/d2ra90020c. eCollection 2022 Mar 1.
3
Drug-eluting intraocular lens with sustained bromfenac release for conquering posterior capsular opacification.用于克服后囊膜混浊的具有持续溴芬酸钠释放功能的药物洗脱人工晶状体。
Bioact Mater. 2021 Jul 23;9:343-357. doi: 10.1016/j.bioactmat.2021.07.015. eCollection 2022 Mar.
4
Centrifugally concentric ring-patterned drug-loaded polymeric coating as an intraocular lens surface modification for efficient prevention of posterior capsular opacification.离心共聚焦环纹载药高分子涂层作为一种眼内透镜表面改性方法，可有效预防后发性白内障。
Acta Biomater. 2022 Jan 15;138:327-341. doi: 10.1016/j.actbio.2021.11.018. Epub 2021 Nov 17.
5
NIR-triggered drug delivery system for chemo-photothermal therapy of posterior capsule opacification.近红外触发的药物输送系统用于后囊膜混浊的化学-光热治疗。
J Control Release. 2021 Nov 10;339:391-402. doi: 10.1016/j.jconrel.2021.09.030. Epub 2021 Sep 23.
6
Foldable Glistening-Free Acrylic Intraocular Lens Biomaterials with Dual-Side Heterogeneous Surface Modification for Postoperative Endophthalmitis and Posterior Capsule Opacification Prophylaxis.具有双面异质表面修饰的折叠式无光泽丙烯酸眼科人工晶体生物材料，可预防术后眼内炎和后囊膜混浊。
Biomacromolecules. 2021 Aug 9;22(8):3510-3521. doi: 10.1021/acs.biomac.1c00582. Epub 2021 Jul 21.
7
Factors Affecting Posterior Capsule Opacification in the Development of Intraocular Lens Materials.人工晶状体材料研发中影响后囊膜混浊的因素
Pharmaceutics. 2021 Jun 10;13(6):860. doi: 10.3390/pharmaceutics13060860.
8
Intraocular lenses as drug delivery devices.人工晶状体作为药物输送装置。
Int J Pharm. 2021 Jun 1;602:120613. doi: 10.1016/j.ijpharm.2021.120613. Epub 2021 Apr 16.
9
Surface modification of intraocular lenses via photodynamic coating for safe and effective PCO prevention.通过光动力涂层对人工晶状体进行表面改性，以安全有效地预防后发性白内障。
J Mater Chem B. 2021 Feb 14;9(6):1546-1556. doi: 10.1039/d0tb02802a. Epub 2021 Feb 2.
10
Surface Modification of Intraocular Lens with Hydrophilic Poly(Sulfobetaine Methacrylate) Brush for Posterior Capsular Opacification Prevention.亲水聚（磺酸甜菜碱甲基丙烯酸酯）刷修饰人工晶状体预防后发性白内障。
J Ocul Pharmacol Ther. 2021 Apr;37(3):172-180. doi: 10.1089/jop.2020.0134. Epub 2021 Jan 26.
Zotero 插件