Department of Ophthalmology, Peking University Third Hospital; Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital.
Department of Ophthalmology, Peking University Third Hospital; Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital;
J Vis Exp. 2023 Jul 7(197). doi: 10.3791/65419.
Posterior capsule opacification (PCO) is a common postoperative complication of extracapsular cataract surgery, which is caused by the proliferation and migration of lens epithelial cells and can affect long-term visual outcomes significantly. The most effective treatment for PCO is neodymium-doped yttrium aluminum garnet (Nd:YAG) laser capsulotomy; however, this treatment is associated with posterior segment complication and can break the stability of capsular bag, affecting the position and function of trifocal or toric intraocular lenses (IOLs). Advances in surgical procedures, IOL design, and pharmacy have reduced the rate of PCO in recent years, concentrating on the inhibition of proliferative lens epithelial cells (LECs). This protocol aimed to clear LECs more thoroughly during phacoemulsification and IOL implantation. The first several steps, including clear corneal incision, continuous circular capsulorhexis, hydrodissection, hydrodelineation, and phacoemulsification, were completed as conventional procedures. After placing the IOL into the capsular bag, rotation of the IOL by at least 360° was performed using an irrigation/aspiration tip or a hook, with slight stress on the posterior capsule. Some residuals occurred in the originally transparent capsular bag after rotation of the IOLs. Then, these materials and the viscoelastic were cleared completely using an irrigation/aspiration system. A clear posterior capsule was observed after the surgery in patients undergoing this method. This method of rotating IOLs is a simple, effective, and safe way to prevent PCO by clearing residual LECs and can be carried out without extra tools or skills.
后囊混浊 (PCO) 是白内障囊外摘除术后的一种常见并发症,是由晶状体上皮细胞的增殖和迁移引起的,会显著影响长期的视觉效果。治疗 PCO 最有效的方法是钕:钇铝石榴石 (Nd:YAG) 激光后囊切开术;然而,这种治疗方法与后节并发症相关,可能会破坏囊袋的稳定性,影响三焦点或散光人工晶状体 (IOL) 的位置和功能。近年来,由于手术技术、人工晶状体设计和药剂学的进步,PCO 的发生率有所降低,主要集中在抑制增殖性晶状体上皮细胞 (LECs) 上。本方案旨在在超声乳化和 IOL 植入过程中更彻底地清除 LECs。前几步,包括透明角膜切口、连续环形撕囊、水分离、水划开和超声乳化,按常规程序进行。将 IOL 植入囊袋后,用灌吸头或钩旋转 IOL 至少 360°,对后囊施加轻微压力。IOL 旋转后,原本透明的囊袋内会出现一些残留物。然后,用灌吸系统彻底清除这些材料和黏弹剂。行该方法的患者术后可观察到后囊清晰。这种旋转 IOL 的方法是一种简单、有效、安全的清除残余 LECs 以预防 PCO 的方法,无需额外的工具或技术。