Department of Pediatrics, Penn State College of Medicine, Hershey, PA, USA.
Clin Pediatr (Phila). 2023 Oct;62(9):1101-1108. doi: 10.1177/00099228231152840. Epub 2023 Feb 7.
Some children and young people (CYP) with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) experience persistent symptoms, commonly called "long COVID." It remains unclear whether symptoms of SARS-CoV-2 persist longer than those of other respiratory viruses, particularly in young children. This cross-sectional study involved 372 CYP (0-15 years) tested for SARS-CoV-2. Character and duration of symptoms (cough, runny nose, sore throat, rash, diarrhea, vomiting, sore muscles, fatigue, fever, loss of smell) were compared between CYP with a positive test (n = 100) and those with a negative test (n = 272), while controlling for medical/demographic covariates. The average duration of symptoms for CYP with a positive SARS-CoV-2 test (8.5 ± 10 days) did not differ from that of CYP with a negative test (7.2 ± 5 days, = .71, d = 0.046). A positive SARS-CoV-2 test did not increase the risk (36/372, 10%) of symptoms persisting for ≥3 weeks (odds ratio = 0.96, 95% confidence interval = 0.45-2.0). These results suggest CYP with non-SARS-CoV-2 infections experience a similar duration of symptoms as peers with SARS-CoV-2 infection.
一些儿童和青少年（CYP）感染严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）后会出现持续症状，通常称为“长新冠”。目前尚不清楚 SARS-CoV-2 的症状是否比其他呼吸道病毒持续时间更长，尤其是在年幼的儿童中。本横断面研究涉及 372 名接受 SARS-CoV-2 检测的 CYP（0-15 岁）。对检测呈阳性（n = 100）和检测呈阴性（n = 272）的 CYP 患者的症状特征和持续时间（咳嗽、流涕、喉咙痛、皮疹、腹泻、呕吐、肌肉酸痛、疲劳、发热、嗅觉丧失）进行比较，同时控制医疗/人口统计学协变量。SARS-CoV-2 检测呈阳性的 CYP 的症状持续时间（8.5 ± 10 天）与检测呈阴性的 CYP （7.2 ± 5 天， =.71，d = 0.046）没有差异。SARS-CoV-2 检测呈阳性并没有增加症状持续≥3 周的风险（36/372，10%）（比值比 = 0.96，95%置信区间 = 0.45-2.0）。这些结果表明，非 SARS-CoV-2 感染的 CYP 经历的症状持续时间与 SARS-CoV-2 感染的同龄人相似。
