Naguib Adrina Mohamad, Apparoo Yasaaswini, Xiong Chuan, Phan Chia Wei
Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.
Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Malaya, 50603 Kuala Lumpur, Malaysia; Mushroom Research Centre, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.
Int J Med Mushrooms. 2023;25(2):11-22. doi: 10.1615/IntJMedMushrooms.2022046849.
Neurodegeneration is one of the most common manifestations in an aging population. The occurrence of oxidative stress and neuroinflammation are the main contributors to the phenomenon. Neurologic conditions such as Alzheimer's disease (AD) and Parkinson's disease (PD) are challenging to treat due to their irreversible manner as well as the lack of effective treatment. Grifola frondosa (Dicks.: Fr.) S.F. Gray, or maitake mushroom, is believed to be a potential choice as a therapeutic agent for neurodegenerative diseases. G. frondosa is known to be a functional food that has a wide variety of medicinal purposes. Thus, this review emphasizes the neuroprotective effects and the chemical composition of G. frondosa. Various studies have described that G. frondosa can protect and proliferate neuronal cells through neurogenesis, antioxidative, anti-inflammatory, and anti-β-amyloid activities. The mechanism of action behind these therapeutic findings in various in vitro and in vivo models has also been intensively studied. In this mini review, we also summarized the chemical composition of G. frondosa to provide a better understanding of the presence of nutritional compounds in G. frondosa.
神经退行性变是老年人群中最常见的表现之一。氧化应激和神经炎症的发生是这一现象的主要促成因素。像阿尔茨海默病（AD）和帕金森病（PD）这样的神经疾病由于其不可逆性以及缺乏有效治疗方法而难以治疗。灰树花（Grifola frondosa (Dicks.: Fr.) S.F. Gray），即舞茸，被认为是神经退行性疾病治疗药物的一个潜在选择。灰树花是一种具有多种药用目的的功能性食品。因此，本综述着重介绍灰树花的神经保护作用及其化学成分。各种研究表明，灰树花可通过神经发生、抗氧化、抗炎和抗β-淀粉样蛋白活性来保护和增殖神经元细胞。在各种体外和体内模型中，这些治疗结果背后的作用机制也得到了深入研究。在本小型综述中，我们还总结了灰树花的化学成分，以便更好地了解灰树花中营养化合物的存在情况。
