Bhattacharya Sanjib
West Bengal Medical Services Corporation Ltd., GN 29, Sector V, Salt Lake City, Kolkata 700091, West Bengal, India.
J Environ Pathol Toxicol Oncol. 2023;42(2):93-99. doi: 10.1615/JEnvironPatholToxicolOncol.2022045311.
Toxicity caused by heavy metals inflicts a grave global menace to the habitat and inhabitants. Arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg) are the non-essential yet harmful heavy metals commonly associated with pollution and resultant health complications. Typical chelating/complexing agents are not worthy of combating heavy metal-induced sub-chronic and chronic toxicities. It transpires from scientific data mining that, honey obviates investigational heavy metal toxicity. This review aims to collate such investigations conducted against As, Cd, and Pb toxicity. There is a total of 19 pre-clinical works demonstrating the ameliorative effect of honey against empirical As, Cd, and Pb toxicity. Pre-clinical reports against Hg and clinical study against these heavy metals could not found. From the outcome of the current literature investigation, it seems that honey has a marked heavy metal toxicity meliorative effect which is chiefly ascribed to its innate antioxidant effect due to its diverse polyphenol content.
重金属造成的毒性对栖息地和居民构成了严重的全球威胁。砷(As)、镉(Cd)、铅(Pb)和汞(Hg)是常见的非必需但有害的重金属,通常与污染及由此引发的健康问题有关。典型的螯合/络合剂对于对抗重金属引起的亚慢性和慢性毒性并无效果。从科学数据挖掘中发现,蜂蜜可消除实验性重金属毒性。本综述旨在整理针对砷、镉和铅毒性进行的此类研究。共有19项临床前研究表明蜂蜜对实验性砷、镉和铅毒性具有改善作用。未找到针对汞的临床前报告以及针对这些重金属的临床研究。从当前文献调查的结果来看,蜂蜜似乎具有显著的重金属毒性改善作用,这主要归因于其多样的多酚含量所具有的固有抗氧化作用。