Department of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Japan.
Medicine (Baltimore). 2023 Feb 3;102(5):e32713. doi: 10.1097/MD.0000000000032713.
Multiple evanescent white dot syndrome (MEWDS) is characterized by multiple white dots in the posterior pole of the eye, but its diagnosis can be difficult in cases when the white dots are not visible. We report an atypical case of MEWDS that developed in pathologic myopia.
A 42-year-old woman presented with floater and reduced and distorted vision in the right eye that she noted 3 days earlier.
The right eye was highly myopic at -17.0 diopters, and her decimal best-corrected visual acuity was reduced to 0.2 (20/100). Fundus examinations revealed no abnormalities other than myopic fundus changes and previous laser photocoagulation spots. However, fundus autofluorescence (FAF) showed multiple hyperfluorescent dots, and optical coherence tomography showed a high reflective lesion on the retinal pigmental epithelium at the fovea. Adjustments of the brightness and contrast of the conventional fundus images revealed white dots in the same location as the hyperfluorescent spots seen in the FAF images. We diagnosed her with MEWDS.
We treated her with systemic administration of 20 mg prednisolone and the dose of prednisolone was reduced by 5 mg every 4 weeks.
The optical coherence tomography and FAF findings gradually normalized, and 5 months later, her decimal visual acuity was restored to 1.0 (20/20).
It was suggested that white dots typical to MEWDS may not be evident in pathologic myopia, and FAF images and the brightness and contrast adjustment of fundus images were useful in the diagnosis of atypical MEWDS.
多发性一过性白点综合征(MEWDS)的特征是眼后极有多发性白点,但当白点不可见时,其诊断可能较为困难。我们报告了一例病理性近视中发生的不典型 MEWDS 病例。
一名 42 岁女性因右眼漂浮物和视力下降(右眼视力下降 3 天前出现)就诊。
右眼高度近视达-17.0 屈光度,她的十进制最佳矫正视力降至 0.2(20/100)。眼底检查除了近视眼底改变和既往激光光凝斑外,未见其他异常。然而,眼底自发荧光(FAF)显示多个高荧光点,光学相干断层扫描(OCT)显示在黄斑区视网膜色素上皮有一个高反射病变。调整常规眼底图像的亮度和对比度后,在与 FAF 图像中高荧光点相同的位置显示出白点。我们诊断为 MEWDS。
我们给予她全身 20mg 泼尼松龙治疗,每 4 周减少 5mg 泼尼松龙剂量。
OCT 和 FAF 检查结果逐渐恢复正常,5 个月后,她的十进制视力恢复至 1.0(20/20)。
提示在病理性近视中,MEWDS 的典型白点可能不明显,FAF 图像和眼底图像的亮度和对比度调整有助于诊断不典型 MEWDS。