比较他莫昔芬和激素替代周期（HRT）在冻融胚胎移植中的应用。一项随机对照试验。

Comparison of tamoxifen and hormone replacement cycle (HRT) in frozen embryo transfer. A randomized controlled trial.

机构信息

Maternal & Neonatal Research Center, Faculty of Medicines, Mashhad University of Medical Sciences, Mashhad, Iran.

Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

JBRA Assist Reprod. 2023 Jun 22;27(2):241-246. doi: 10.5935/1518-0557.20220078.

DOI:10.5935/1518-0557.20220078

PMID:36749805

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10279440/

Abstract

OBJECTIVE

The use of frozen embryos in the treatment of infertility with assisted reproductive techniques has been increased. Different methods are used to prepare the endometrium for frozen embryo transfer (FET). The aim of this study was to compare pregnancy outcomes after treatment with tamoxifen and hormonal replacement therapy (HRT) in FET.

METHODS

This randomized clinical trial was carried out with 214 infertile women in the infertility research center of Milad Hospital in Mashhad during 2018-2020. We had 84 patients receiving tamoxifen and 92 took HRT. Endometrial thickness (ET) and pregnancy outcome were measured in both groups.

RESULTS

Mean infertility duration (p=0.328), number of embryos (p=0.649), FSH (p=0.390), LH (p=0.051) and LH/FSH ratio (p=0.287) as well as type of infertility (primary or secondary) (p=0.295), causes of infertility (p=0.750) and pattern of menstruation (p=0.676) were not significantly different in the two groups. Mean ET in the TMX and HRT groups were 8.72±1.45mm and 9.00±1.69mm, respectively (p=0.423). There was no statistically significant difference between chemical pregnancy (p=0.663), clinical pregnancy (p=0.994) and ongoing pregnancy (p≥0.999) in the TMX and HRT groups.

CONCLUSIONS

Treatment with tamoxifen can be as effective as GnRH agonist for endometrial preparation in FET.

摘要

目的

随着辅助生殖技术的应用，冷冻胚胎在治疗不孕中的应用越来越多。为了进行冻融胚胎移植（FET），人们采用了不同的方法来准备子宫内膜。本研究旨在比较他莫昔芬和激素替代疗法（HRT）在 FET 中的治疗效果。

方法

这项随机临床试验在 2018 年至 2020 年期间在马什哈德米拉德医院的不孕不育研究中心进行，共有 214 名不孕女性参与，其中 84 名接受他莫昔芬治疗，92 名接受 HRT。两组均测量了子宫内膜厚度（ET）和妊娠结局。

结果

两组的不孕持续时间（p=0.328）、胚胎数量（p=0.649）、FSH（p=0.390）、LH（p=0.051）和 LH/FSH 比值（p=0.287）以及不孕类型（原发性或继发性）（p=0.295）、不孕原因（p=0.750）和月经模式（p=0.676）均无显著差异。TMX 和 HRT 组的平均 ET 分别为 8.72±1.45mm 和 9.00±1.69mm（p=0.423）。TMX 和 HRT 组的化学妊娠（p=0.663）、临床妊娠（p=0.994）和持续妊娠（p≥0.999）均无统计学差异。