Asherson R A, Muncey F, Pambakian H, Brostoff J, Hughes G R
Lupus Arthritis Research Unit, Rayne Institute, St Thomas's Hospital, London.
Ann Rheum Dis. 1987 Sep;46(9):701-5. doi: 10.1136/ard.46.9.701.
The case of a middle aged woman who presented with fibrosing alveolitis, in her mid-forties, followed by a sicca syndrome and who subsequently developed a pulmonary lymphoma (B cell) while receiving azathioprine therapy is recorded. Of interest was the absence of polyclonal B cell activation, e.g., production of rheumatoid factor, hypergammaglobulinaemia, high titre antinuclear antibodies or antibodies to extractable nuclear antigens (ENA) during most of her illness. Persistently raised IgM levels and low IgA levels were demonstrated. The relevance of azathioprine to development of the lymphoma is discussed.
记录了一名中年女性的病例，该女性在四十多岁时出现纤维化肺泡炎，随后出现干燥综合征，并在接受硫唑嘌呤治疗时继发肺淋巴瘤（B细胞型）。有趣的是，在她病程的大部分时间里，未出现多克隆B细胞激活，例如类风湿因子产生、高球蛋白血症、高滴度抗核抗体或可提取核抗原（ENA）抗体。检测到IgM水平持续升高而IgA水平降低。讨论了硫唑嘌呤与淋巴瘤发生的相关性。
