Sugai S, Takiguchi T, Hirose Y, Shimizu S, Tachibana J, Konda S, Konishi F
Jpn J Med. 1985 May;24(2):155-63. doi: 10.2169/internalmedicine1962.24.155.
We report a patient with progressive systemic sclerosis (PSS) and Sjogren's syndrome (SS) who developed B cell malignant lymphoma 11 and 10 years after the onset of signs of PSS and SS, respectively. As her lymphoma developed, autoantibodies such as rheumatoid factor and antinuclear antibody disappeared from the serum, the lupus erythematosus test yielded negative results and her immunoglobulin levels declined. A good response to chemotherapy was obtained but she died of acute interstitial pneumonitis. Postmortem examination revealed marked diffuse interstitial fibrosis of the lungs.
我们报告了一名患有进行性系统性硬化症（PSS）和干燥综合征（SS）的患者，分别在PSS和SS症状出现后的11年和10年发展为B细胞恶性淋巴瘤。随着淋巴瘤的发展，血清中的类风湿因子和抗核抗体等自身抗体消失，红斑狼疮试验结果呈阴性，她的免疫球蛋白水平下降。化疗取得了良好的反应，但她死于急性间质性肺炎。尸检显示肺部有明显的弥漫性间质纤维化。
