Studer J P, Glauser M P, Schapira M
Br Med J. 1979 Jan 13;1(6156):85-6. doi: 10.1136/bmj.1.6156.85.
To determine the significance of the presence of intragranulocytic micro-organisms in the blood buffy coat in patients with suspected infection, buffy coat examination and blood cultures were simultaneously performed in 455 consecutive patients with fever. There was no general correlation between the finding of intragranulocytic micro-organisms in the buffy coat and positive blood cultures. Patients with persistent bacteraemia and sterile blood cultures were, however, shown to have persistently positive buffy coat findings on repeated examination. These patients, who had culture-negative endocarditis or catheter-associated infections, had sterile blood cultures because of antibiotic treatment. Repeated positive findings in the buffy coat may therefore be valuable in detecting patients with persistent bacteraemia, but sporadic findings of micro-organisms in the buffy coats of acutely ill patients seem to have little diagnostic value.
为确定疑似感染患者血中白细胞层内粒细胞内微生物存在的意义，对455例连续发热患者同时进行了白细胞层检查和血培养。白细胞层中粒细胞内微生物的发现与血培养阳性之间无普遍相关性。然而，持续性菌血症且血培养无菌生长的患者，经反复检查显示白细胞层检查持续呈阳性。这些患有培养阴性的心内膜炎或导管相关感染的患者，由于抗生素治疗，血培养无菌生长。因此，白细胞层反复出现阳性结果可能对检测持续性菌血症患者有价值，但急性病患者白细胞层中微生物的偶发发现似乎诊断价值不大。
