Priestman T, Baum M, Jones V, Forbes J
Br Med J. 1978 Dec 16;2(6153):1673-4. doi: 10.1136/bmj.2.6153.1673.
The final results of a clinical trial comparing endocrine with cytotoxic drug treatment for advanced breast cancer were analysed. Although cytotoxic treatment gave a significantly higher response rate with a remission duration comparable to that obtained with endocrine treatment, the sequence in which the two treatments were given did not appear to influence survival--except possibly in women with rapidly progressing disease, when cytotoxic treatment is preferred.
对一项比较内分泌治疗与细胞毒性药物治疗晚期乳腺癌的临床试验的最终结果进行了分析。尽管细胞毒性治疗的缓解率显著更高,缓解持续时间与内分泌治疗相当,但两种治疗的给药顺序似乎并未影响生存率——可能快速进展性疾病的女性除外,这类患者首选细胞毒性治疗。