晚期乳腺癌中细胞毒性化疗与激素治疗的同步或序贯使用：瑞士临床癌症研究组报告
Concurrent or sequential use of cytotoxic chemotherapy and hormone treatment in advanced breast cancer: report of the Swiss Group for Clinical Cancer Research.
作者信息
Cavalli F, Beer M, Martz G, Jungi W F, Alberto P, Obrecht J P, Mermillod B, Brunner K W
出版信息
Br Med J (Clin Res Ed). 1983 Jan 1;286(6358):5-8. doi: 10.1136/bmj.286.6358.5.
Abstract
In a trial of combined hormone treatment and cytotoxic chemotherapy 464 patients with advanced breast cancer were randomly allocated to either concurrent or sequential treatment. Cytotoxic drugs were given only if the antitumour activity of the hormone treatment was inadequate. Hormone treatment consisted of oophorectomy for premenopausal and tamoxifen administration for postmenopausal patients. Length of survival was better, though not significantly, in premenopausal patients (p = 0.29) treated concurrently and in postmenopausal women (p = 0.17) treated sequentially; the difference was highly significant (p = 0.003) only for postmenopausal women in the low-risk category. The findings suggest that postmenopausal women with metastatic breast cancer should probably be treated primarily by carefully monitored hormone treatment.
摘要
在一项联合激素治疗与细胞毒性化疗的试验中，464例晚期乳腺癌患者被随机分配接受同步治疗或序贯治疗。仅在激素治疗的抗肿瘤活性不足时才给予细胞毒性药物。激素治疗包括对绝经前患者进行卵巢切除术，对绝经后患者给予他莫昔芬。绝经前同步治疗的患者（p = 0.29）和绝经后序贯治疗的女性（p = 0.17）的生存期虽无显著改善，但有所延长；仅低风险类别的绝经后女性差异具有高度显著性（p = 0.003）。研究结果表明，转移性乳腺癌的绝经后女性可能应以密切监测的激素治疗为主。
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