Teucher G, Schindler A E
Universitäts-Frauenklinik Tübingen.
Arch Geschwulstforsch. 1987;57(4):309-17.
Retrospectively 378 patients with primary cancer of all stages, treated between 1975 and 1982 were studied again after an interval of at least 3 years. During this time 75 (19.8%) tumor recurrences were observed; in 47 cases (12.4%) distant metastases and in 28 cases (7.4%) local recurrences. Fever was defined as body temperature above 37.5 degrees C from the second postoperative day onward. Postoperative fever occurred in 45% of the patients; stage I 41%, stage II 45%, stage III 59% and stage IV 50%. Considering tumor recurrence there was a fever frequency of 69%, irrespective of stage, which in stage III reached 86% in cases with distant metastases and even 100% in cases with local recurrence. In comparison fever frequency in patients without evidence of recurrence was 36% to 40%. The relative risk of recurrence after postoperative fever increases significantly: in stage II 2.4 times and in stage III 10.6 times. Analysis of postoperative fever revealed, that short drainage time below 6 days and volumes of drained fluid below 400 ml were prognostically infavorable, while wound complications were not associated with an increased risk of tumor recurrence.
回顾性研究了1975年至1982年间接受治疗的378例各期原发性癌症患者，在至少3年的间隔期后再次对其进行研究。在此期间，观察到75例（19.8%）肿瘤复发；47例（12.4%）发生远处转移，28例（7.4%）发生局部复发。发热定义为术后第二天起体温高于37.5摄氏度。45%的患者出现术后发热；I期为41%，II期为45%，III期为59%，IV期为50%。考虑到肿瘤复发，无论分期如何，发热频率为69%，其中III期远处转移患者发热频率达86%，局部复发患者甚至达100%。相比之下，无复发证据患者的发热频率为36%至40%。术后发热后复发的相对风险显著增加：II期增加2.4倍，III期增加10.6倍。对术后发热的分析显示，引流时间短于6天且引流量低于400毫升在预后方面不利，而伤口并发症与肿瘤复发风险增加无关。
