长链非编码RNA MALAT1促进乳腺癌术后发热患者复发。
LncRNA MALAT1 promotes relapse of breast cancer patients with postoperative fever.
作者信息
Li Zhihua, Xu Liang, Liu Yong, Fu Shaokun, Tu Jianhong, Hu Yangyang, Xiong Qiuyun
机构信息
Department of Breast Surgery, The Third Hospital of Nanchang City Nanchang 330009, Jiangxi, People's Republic of China.
Key Laboratory of Breast Diseases in Jiangxi Province Nanchang 330009, Jiangxi, People's Republic of China.
出版信息
Am J Transl Res. 2018 Oct 15;10(10):3186-3197. eCollection 2018.
Postoperative fever is prevalent in many breast cancer patients. Some retrospective studies proposed that postoperative fever might also be considered as a rapid rough indicator for the poor prognosis of breast cancer patients. This study aims to explore the possible molecular mechanisms underlying the relapse of breast cancer patients with early postoperative fever. Our results indicated plasma levels of lncRNA MALAT1 were elevated in breast cancer patients with early postoperative fever and were associated with RFS. Lipopolysaccharide (LPS) was able to induce fever and systemic inflammatory responses in 4T1 xenograft mice, and promote lung metastasis. But after knocking down lncRNA MALAT1, the inflammatory responses and metastasis of lung were significantly reduced. Moreover, after knocking down lncRNA MALAT1 in the 4T1 cells, TNF-α level in the supernatants was sharply decreased, and the invasion and migration induced by LPS was also weakened. Cumulatively, our data indicates that MALAT1 is closely related to recurrence and metastasis of breast cancer patients with early postoperative fever.
术后发热在许多乳腺癌患者中很常见。一些回顾性研究表明，术后发热也可能被视为乳腺癌患者预后不良的一个快速粗略指标。本研究旨在探讨术后早期发热的乳腺癌患者复发的潜在分子机制。我们的结果表明，lncRNA MALAT1的血浆水平在术后早期发热的乳腺癌患者中升高，并且与无复发生存期相关。脂多糖（LPS）能够在4T1异种移植小鼠中诱导发热和全身炎症反应，并促进肺转移。但敲低lncRNA MALAT1后，肺部的炎症反应和转移明显减少。此外，在4T1细胞中敲低lncRNA MALAT1后，上清液中的TNF-α水平急剧下降，LPS诱导的侵袭和迁移也减弱。累积而言，我们的数据表明MALAT1与术后早期发热的乳腺癌患者的复发和转移密切相关。
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