在接受静脉注射万古霉素的门诊患者中，基于曲线下面积监测和基于谷浓度监测所产生的剂量调整仅在治疗谷浓度范围的极值处有所不同。
In Outpatients Receiving Parenteral Vancomycin, Dosing Adjustments Produced by Area Under the Curve-Based and Trough-Based Monitoring Differ Only at the Extremes of the Therapeutic Trough Range.
作者信息
Shi Yufei, Alexander Bryan T, Avedissian Sean, Bergman Scott J, Cortés-Penfield Nicolás
机构信息
University of Nebraska Medical Center, College of Pharmacy, Omaha, Nebraska, USA.
Department of Pharmacy, Nebraska Medicine, Omaha, Nebraska, USA.
出版信息
Open Forum Infect Dis. 2023 Jan 7;10(2):ofac696. doi: 10.1093/ofid/ofac696. eCollection 2023 Feb.
Abstract
Area under the curve (AUC)-based vancomycin dosing reduces nephrotoxicity but is burdensome. Reviewing 115 adults receiving ≥2 weeks of outpatient vancomycin, we found AUC-based and trough-based dose adjustments discordant only for troughs <12 or >16 mg/L. Selective versus universal outpatient AUC calculation would likely offer similar benefit with reduced workload.
摘要
基于曲线下面积（AUC）的万古霉素给药方案可降低肾毒性，但操作繁琐。在对115名接受≥2周门诊万古霉素治疗的成年人进行回顾时，我们发现，仅当谷浓度<12或>16mg/L时，基于AUC和基于谷浓度的剂量调整才不一致。选择性而非普遍性的门诊AUC计算可能在减轻工作量的同时带来相似的益处。
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