State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China.
J Zhejiang Univ Sci B. 2023 Feb 15;24(2):101-114. doi: 10.1631/jzus.B2200178.
Given its state of stable proliferative inhibition, cellular senescence is primarily depicted as a critical mechanism by which organisms delay the progression of carcinogenesis. Cells undergoing senescence are often associated with the alteration of a series of specific features and functions, such as metabolic shifts, stemness induction, and microenvironment remodeling. However, recent research has revealed more complexity associated with senescence, including adverse effects on both physiological and pathological processes. How organisms evade these harmful consequences and survive has become an urgent research issue. Several therapeutic strategies targeting senescence, including senolytics, senomorphics, immunotherapy, and function restoration, have achieved initial success in certain scenarios. In this review, we describe in detail the characteristic changes associated with cellular senescence and summarize currently available countermeasures.
鉴于其稳定的增殖抑制状态，细胞衰老主要被描绘为生物体延缓致癌作用进展的关键机制。衰老细胞通常与一系列特定特征和功能的改变相关，例如代谢转变、干性诱导和微环境重塑。然而，最近的研究揭示了与衰老相关的更多复杂性，包括对生理和病理过程的不利影响。生物体如何逃避这些有害后果并存活下来已成为一个紧迫的研究问题。几种针对衰老的治疗策略，包括衰老细胞清除剂、衰老模拟物、免疫疗法和功能恢复，在某些情况下已取得初步成功。在这篇综述中，我们详细描述了与细胞衰老相关的特征性变化，并总结了目前可用的对策。
