梅毒螺旋体免疫黏附试验用于梅毒的血清学诊断。3：临床意义及治疗评估
Treponema pallidum immune adherence test for serodiagnosis of syphilis. 3: Clinical significance and evaluation of treatment.
作者信息
Tanaka S, Suzuki T, Numata T
出版信息
Br J Vener Dis. 1978 Dec;54(6):380-5. doi: 10.1136/sti.54.6.380.
Antibody titres were measured in patients with clinical syphilis, and the effect of treatment on the results of the Treponema pallidum immune adherence (TPIA) test is reported. In the Treponema pallidum haemagglutination (TPHA) test little change in antibody titre occurred after treatment while in the fluorescent treponemal antibody-absorbed (FTA-ABS) test only a slight decrease occurred. The decrease in the antibody titre in the TPIA test was similar to that in the glass plate test, but the findings were different. From the results of gel filtration of sera obtained from patients with syphilis at different intervals after treatment it was apparent that the decrease in antibody titre after treatment mainly concerned the IgM antibody; thus, because of the high sensitivity of the TPIA test to IgM antibody the test is useful in evaluating the effect of treatment.
对临床梅毒患者的抗体滴度进行了测量，并报告了治疗对梅毒螺旋体免疫粘附（TPIA）试验结果的影响。在梅毒螺旋体血凝试验（TPHA）中，治疗后抗体滴度变化不大，而在荧光密螺旋体抗体吸收试验（FTA-ABS）中，仅出现轻微下降。TPIA试验中抗体滴度的下降与玻璃板试验相似，但结果有所不同。从治疗后不同时间间隔的梅毒患者血清的凝胶过滤结果来看，治疗后抗体滴度的下降主要涉及IgM抗体；因此，由于TPIA试验对IgM抗体具有高敏感性，该试验在评估治疗效果方面很有用。
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