Brown R H, Zilis J D, Lynch M G, Sanborn G E
Department of Ophthalmology, University of Texas Health Science Center, Dallas 75235-9057.
Arch Ophthalmol. 1987 Nov;105(11):1540-3. doi: 10.1001/archopht.1987.01060110086038.
The OCTOPUS 2000 perimeter and a central 30 degrees program were used to study consecutively 27 patients with glaucoma who had either a relative afferent pupillary defect (APD) or asymmetric optic nerve cupping without an APD. The mean difference in visual field sensitivity between fellow eyes was 48.2% (range, 13% to 93%) for the APD group and 5.5% (range, 0% to 9.0%) for the non-APD group. The mean difference in cup-disc ratio was 0.43 (range, 0.2 to 0.6) for the APD group and 0.24 (range, 0.2 to 0.3) for the non-APD group. The APD depth was quantitated with neutral density filters and correlated with visual field asymmetry but not with cup-disc ratio asymmetry. There was no overlap between the APD and non-APD groups in the amount of visual field asymmetry: Every patient with a sensitivity difference of 13% or greater had an APD. The presence of an APD indicates that a threshold of asymmetric optic nerve damage has been exceeded. With automated perimetry, this threshold can be quantitated and may improve the assessment of patients with glaucoma.
采用OCTOPUS 2000视野计及中央30度程序，对27例青光眼患者进行了连续研究，这些患者要么存在相对传入性瞳孔缺陷（APD），要么存在不对称视神经杯状凹陷但无APD。APD组患眼与对侧眼之间视野敏感度的平均差异为48.2%（范围为13%至93%），非APD组为5.5%（范围为0%至9.0%）。APD组杯盘比的平均差异为0.43（范围为0.2至0.6），非APD组为0.24（范围为0.2至0.3）。使用中性密度滤光片对APD深度进行定量，并与视野不对称相关，但与杯盘比不对称无关。APD组和非APD组在视野不对称程度上没有重叠：每例敏感度差异为13%或更大的患者都有APD。APD的存在表明已经超过了不对称视神经损伤的阈值。通过自动视野检查，这个阈值可以定量，并且可能改善青光眼患者的评估。
