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[孕期登革热,血小板减少症的发病率低于普通人群]

[Dengue during pregnancy, less incidence of thrombocytopenia than in general population].

作者信息

Gutiérrez-Aguirre Cesar H, Palomares-Leal Alain, Soto-Flores Laura, Colunga-Pedraza Perla, Jaime-Pérez José C, Zambrano-Velarde Miguel, Vega-Cortes Dante, Flores-Jiménez Juan A, Gómez-Almaguer David

机构信息

CG: MD. Internista y Hematólogo. M. Sc.; Ph. D. Bioética. Universidad Autónoma de Nuevo León, Servicio de Hematología del Hospital Universitario "Dr. José Eleutério González". Monterrey N.L. México.

AP: MD. Universidad Autónoma de Nuevo León, Servicio de Hematología del Hospital Universitario "Dr. José Eleuterio González". Monterrey N.L. México.

出版信息

Rev Salud Publica (Bogota). 2019 Sep 1;21(5):549-554. doi: 10.15446/rsap.V21n5.76916.

DOI:10.15446/rsap.V21n5.76916
PMID:36753207
Abstract

OBJECTIVE

Dengue is a generally self-limited viral disease, considered a public health problem in Mexico. It can be accompanied by laboratory alterations such as neutropenia, lymphopenia and thrombocytopenia. The objective of the study was to evaluate the incidence of hematological alterations in patients with dengue.

METHODS

We retrospectively included 64 patients, including 14 pregnant women, with a diagnosis of dengue at the Hospital Universitario de Monterrey and Civil Nuevo de Guadalajara from January 2014 to December 2017.

RESULTS

The most common clinical symptom in the general group was headache and retro-ocular pain in 53 patients (83%), while in pregnant patients it was fever in 12 patients (86%). The median platelet count in the general group was 51.4x103/ μ!, with thrombocytopenia in 88% of patients, while in pregnant patients it was 141.1 x103/ with thrombocytopenia in 57% of patients (p=0.002). Platelet recovery was achieved in 7 days in the general group and 4.5 days in pregnant patients.

CONCLUSIONS

Contrary to that reported in the literature, pregnant patients had a lower incidence of thrombocytopenia and a higher platelet count at time of diagnosis without impact on maternal mortality or in the course of pregnancy.

摘要

目的

登革热是一种通常自限性的病毒性疾病,在墨西哥被视为公共卫生问题。它可能伴有如中性粒细胞减少、淋巴细胞减少和血小板减少等实验室检查异常。本研究的目的是评估登革热患者血液学异常的发生率。

方法

我们回顾性纳入了2014年1月至2017年12月期间在蒙特雷大学医院和瓜达拉哈拉市民新医院诊断为登革热的64例患者,其中包括14例孕妇。

结果

普通组最常见的临床症状是53例患者(83%)出现头痛和眼球后疼痛,而孕妇中最常见的症状是12例患者(86%)出现发热。普通组血小板计数中位数为51.4×10³/μL,88%的患者有血小板减少,而孕妇血小板计数中位数为141.1×10³/μL,57%的患者有血小板减少(p = 0.002)。普通组患者7天实现血小板恢复,孕妇患者4.5天实现血小板恢复。

结论

与文献报道相反,孕妇血小板减少的发生率较低,诊断时血小板计数较高,且对孕产妇死亡率或妊娠过程无影响。

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引用本文的文献

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Clinical outcomes of dengue virus infection in pregnant and non-pregnant women of reproductive age: a retrospective cohort study from 2016 to 2019 in Paraná, Brazil.2016 年至 2019 年巴西巴拉那州妊娠和非妊娠育龄妇女登革热病毒感染的临床结局:一项回顾性队列研究。
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