Mir Munazza, Khurshid Rukhshan, Aftab Roohi
J Ayub Med Coll Abbottabad. 2012 Jul-Dec;24(3-4):6-9.
Incidence of dengue increased 30 fold between 1960 and 2010. This increase is believed to be due to a combination of urbanisation, population growth, increased international travel, and global warming. We tried to find out the effect of herbal water of Tawa-tawa, also called Euphorbia hirta, on the flu like symptoms and blood parameters especially on thrombocytopenia.
Total 125 patients with confirmed dengue fever admitted in medical ward of Sir Ganga Ram Hospital Lahore were included in this experimental study. Duration of study was 3 months. Patients were divided into 2 groups, i.e., group A (ages between 30 to 55 years) and group B (ages between 14 to 25 years). A blood sample was obtained on the day of enrolment and after 24 hours of using Tawa-tawa. The variables used were platelet count, haematocrit (HCT), WBC count, serum AST, ALT, IgM/IgG.
In men, platelet count was < 25,000 and in women, it was > 50,000. Haematocrit were >40% in men and 30-40% in women. TLC in a range of 4,000-11,000/mm3 was observed in both males and females. IgM 'haemagglutination' antibody titres (> 1:160) was observed in 71.3% females and 50% males. Serum AST was > 40 IU/L in 38% females and 36% males. Serum ALT was > 40 IU/L in 9.5% females and 12% males. In both group A and B platelet count and TLC were increased nonsignificantly after herbal water of Euphorbia hirta (E. Hirta). Haematocrit value decreased nonsignificantly after using the herbal water. Over 70% of patients showed moderate increase in their platelet count. However leucopoenia improved significantly after the use of aqueous extract of E. hirta. A marked recovery in fever and flu like symptoms was observed.
In over 70% patients there was improvement in platelet count, TLC, fever, and flue-like symptoms.
1960年至2010年间，登革热发病率增长了30倍。人们认为这种增长是城市化、人口增长、国际旅行增加和全球变暖共同作用的结果。我们试图探究大戟草（也称为千根癀）的草药水对流感样症状和血液参数，尤其是对血小板减少症的影响。
本实验研究纳入了拉合尔甘加拉姆爵士医院内科病房收治的125例确诊登革热患者。研究持续时间为3个月。患者分为两组，即A组（年龄在30至55岁之间）和B组（年龄在14至25岁之间）。在入组当天和使用大戟草24小时后采集血样。所使用的变量包括血小板计数、血细胞比容（HCT）、白细胞计数、血清谷草转氨酶（AST）、谷丙转氨酶（ALT）、IgM/IgG。
男性血小板计数<25,000，女性血小板计数>50,000。男性血细胞比容>40%，女性血细胞比容为30 - 40%。男性和女性白细胞计数均在4,000 - 11,000/mm³范围内。71.3%的女性和50%的男性观察到IgM“血凝”抗体滴度（>1:160）。38%的女性和36%的男性血清AST>40 IU/L。9.5%的女性和12%的男性血清ALT>40 IU/L。在A组和B组中，使用大戟草的草药水后血小板计数和白细胞计数均有非显著性增加。使用草药水后血细胞比容值有非显著性下降。超过70%的患者血小板计数有中度增加。然而，使用大戟草水提取物后白细胞减少症有显著改善。观察到发热和流感样症状有明显缓解。
超过70%的患者血小板计数、白细胞计数、发热和流感样症状均有改善。
