Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.
Graduate School of Clinical Psychology, Teikyo Heisei University, Toshima-ku, Japan.
Neuropsychopharmacol Rep. 2023 Mar;43(1):141-145. doi: 10.1002/npr2.12322. Epub 2023 Feb 8.
Studies showed that cognitive function affects occupational function in patients with schizophrenia. This study aimed to determine the effects of cognitive function on occupational function in Japanese patients with schizophrenia using the Brief Assessment of Cognition in Schizophrenia (BACS).
Participants were 198 outpatients with schizophrenia or schizoaffective disorder (66 females; mean age 34.5 ± 6.8 years). Occupational function was assessed using the work subscale of the Life Assessment Scale for Mental Ill (LASMI-w). Multiple regression analysis was performed using the BACS as the independent variable and LASMI-w as the dependent variable. Furthermore, we divided the LASMI-w score into three groups, <11, 11-20, and >21, and performed a multinomial logistic regression analysis.
Multiple regression analysis revealed that LASMI-w score was negatively associated with BACS composite score (β = -0.20, p < 0.01). Among the sub-items of the BACS, only the symbol-coding score showed a significant negative association (β = -0.19, p < 0.05). Multinomial logistic analysis showed that the better the composite and symbol coding scores, the smaller the impairment of the occupational function (composite score: β = 2.39 between mild and moderate occupational impairments, p < 0.05; symbol coding score: β = 2.44 between mild and severe impairments, p < 0.05).
The occupational function of patients with schizophrenia was associated with overall cognitive function (composite score). In particular, the symbol coding score of the BACS was suggested to be related to work ability. These results might be useful in the assessment and training of cognitive rehabilitation aimed at employment support.
研究表明认知功能会影响精神分裂症患者的职业功能。本研究旨在使用Brief Assessment of Cognition in Schizophrenia（BACS）评估日本精神分裂症患者认知功能对职业功能的影响。
参与者为 198 名精神分裂症或分裂情感障碍门诊患者（66 名女性；平均年龄 34.5±6.8 岁）。使用精神障碍生活评估量表的工作分量表（LASMI-w）评估职业功能。将 BACS 作为自变量，LASMI-w 作为因变量进行多元回归分析。此外，我们将 LASMI-w 评分分为<11、11-20 和>21 三组，进行多项逻辑回归分析。
多元回归分析显示，LASMI-w 评分与 BACS 综合评分呈负相关（β=-0.20，p<0.01）。在 BACS 的子项目中，只有符号编码评分与 LASMI-w 评分呈显著负相关（β=-0.19，p<0.05）。多项逻辑回归分析显示，BACS 综合评分和符号编码评分越高，职业功能受损程度越低（综合评分：轻度和中度职业功能障碍组之间差异有统计学意义，β=2.39，p<0.05；符号编码评分：轻度和重度职业功能障碍组之间差异有统计学意义，β=2.44，p<0.05）。
精神分裂症患者的职业功能与整体认知功能（综合评分）相关。特别是 BACS 的符号编码评分与工作能力相关。这些结果可能有助于评估和训练认知康复，以支持就业。
