Dyer D C, Van Alstine W G
Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Iowa State University, Ames 50011.
Avian Dis. 1987 Jul-Sep;31(3):677-9.
Oxytetracycline hydrochloride (OTC) was delivered to adult parakeets by aerosolization using a DeVilbiss model 65 ultrasonic nebulizer. Trachea, lung, and plasma concentrations were ascertained at 1, 2, 4, 6, and 8 hours postaerosolization (PA). An average of 284 ml of a solution containing 2 mg OTC/ml was aerosolized over a 1-hour period into a 0.0596 M3 chamber containing 10 parakeets. The trachea and lung concentrations were more than 10 micrograms/g at 1 and 2 hours PA, had decreased to approximately 3 micrograms/g by 4 hours PA, and were below 2 micrograms/g by 8 hours. The plasma concentration never exceeded 2.6 micrograms/ml and was at 1.6 micrograms/ml by 8 hours. This study demonstrates that it is possible to achieve therapeutic concentrations of OTC by aerosolization in lung and trachea, but treatment may need to be repeated every 4-6 hours. Since the plasma concentration never reached high levels, aerosolization under the conditions of this study is not an effective way to treat systemic infections outside the respiratory tract.
使用德维比斯65型超声雾化器通过雾化给药，将盐酸土霉素（OTC）给予成年长尾小鹦鹉。在雾化后（PA）1、2、4、6和8小时测定气管、肺和血浆浓度。在1小时内，将平均284毫升含2毫克OTC/毫升的溶液雾化到一个含有10只长尾小鹦鹉的0.0596立方米的舱室内。雾化后1和2小时，气管和肺浓度超过10微克/克，到雾化后4小时降至约3微克/克，到8小时低于2微克/克。血浆浓度从未超过2.6微克/毫升，到8小时时为1.6微克/毫升。本研究表明，通过雾化在肺和气管中可达到OTC的治疗浓度，但可能需要每4 - 6小时重复治疗。由于血浆浓度从未达到高水平，在本研究条件下雾化不是治疗呼吸道外全身感染的有效方法。
