Fox R A, Keil L C, Daunton N G, Crampton G H, Lucot J
Department of Psychology, San Jose State Univ., CA 95192.
Aviat Space Environ Med. 1987 Sep;58(9 Pt 2):A143-7.
Levels of arginine vasopressin (AVP) in blood plasma and cerebrospinal fluid (CSF) were measured in cats under several motion-sickness-inducing conditions. Plasma AVP increased significantly in both susceptible and resistant animals exposed to motion. When vomiting occurred, levels of plasma AVP were dramatically elevated (up to 27 times resting levels). There was no difference in resting levels of AVP of susceptible and resistant cats. Levels of CSF-AVP were not elevated immediately after vomiting, but the resting levels of CSF-AVP were lower in animals that vomited during motion than in those animals which did not vomit during motion. The results of these experiments show that changes in systemic AVP are directly related to vomiting induced by motion, however, CSF-AVP apparently does not change in association with vomiting. CSF-AVP does appear to be lower in animals that reach frank vomiting during motion stimulation than in animals which do not vomit.
在几种诱导晕动病的条件下，对猫的血浆和脑脊液（CSF）中的精氨酸加压素（AVP）水平进行了测量。在暴露于运动的易感和抗性动物中，血浆AVP均显著增加。呕吐发生时，血浆AVP水平急剧升高（高达静息水平的27倍）。易感和抗性猫的AVP静息水平没有差异。呕吐后脑脊液AVP水平没有立即升高，但在运动期间呕吐的动物中，脑脊液AVP的静息水平低于在运动期间未呕吐的动物。这些实验结果表明，全身AVP的变化与运动引起的呕吐直接相关，然而，脑脊液AVP显然不会随呕吐而变化。在运动刺激期间出现明显呕吐的动物中，脑脊液AVP似乎比不呕吐的动物更低。
