Faculty of Life Science and Food Engineering, HuaiYin Institute of Technology, 223003, Huaian, P. R. China.
Jiangsu Provincial Engineering Laboratory for Biomass Conversion and Process Integration, Huaiyin Institute of Technology, 223003, Huaian, PR China.
World J Microbiol Biotechnol. 2023 Feb 9;39(4):93. doi: 10.1007/s11274-023-03531-5.
Glucosamine (GlcN) is a natural amino monosaccharide in which a hydroxyl group of glucose is substituted by an amino group. It belongs to functional amino sugar compounds. In the traditional preparation process, GlcN and GlcNAc are obtained by hydrolyzing the cell wall of shrimp and crab. There are many potential problems with this method, such as geographical and seasonal restrictions on the supply of raw materials, serious environmental pollution and potential allergic reactions. Microbial fermentation has the advantages of mild conditions, low environmental pollution, high production intensity, and product safety. It can effectively solve the problem of shrimp and crab hydrolysis process, attracting many researchers to participate in the research of microbial fermentation production of GlcN. This paper mainly summarizes the research on strain construction method, metabolic pathway design and fermentation condition optimization in microbial fermentation, which has certain guiding significance for the further production, research and production of glucosamine.
氨基葡萄糖（GlcN）是一种天然的氨基单糖，其中葡萄糖的一个羟基被氨基取代。它属于功能氨基糖化合物。在传统的制备过程中，GlcN 和 GlcNAc 是通过水解虾和蟹的细胞壁获得的。这种方法存在许多潜在问题，例如原料供应的地理和季节性限制、严重的环境污染和潜在的过敏反应。微生物发酵具有条件温和、环境污染低、生产强度高、产品安全等优点。它可以有效地解决虾和蟹水解过程中的问题，吸引了许多研究人员参与微生物发酵生产 GlcN 的研究。本文主要总结了微生物发酵中菌株构建方法、代谢途径设计和发酵条件优化的研究，对氨基葡萄糖的进一步生产、研究和生产具有一定的指导意义。
