Abbas Ramsha, Abbas Aiza, Khan Talha Kamran, Sharjeel Salal, Amanullah Khadija, Irshad Yusra
Institute of Molecular Cardiology, Department of Medicine, University of Louisville, Louisville, KY, USA.
Medical College, Aga Khan University, Karachi, Sindh, Pakistan.
J Clin Med Res. 2023 Jan;15(1):1-9. doi: 10.14740/jocmr4823. Epub 2023 Jan 24.
Sudden cardiac death (SCD) can affect all age groups, including young persons. While less common in the age < 35 population, the occurrence of SCD in the young raises concern, with multiple possible etiologies and often unanswered questions. While coronary artery disease is the leading cause in those > 35 years of age, the younger population faces a different subset of pathologies associated with SCD, including arrhythmias and cardiomyopathies. The tragic nature of SCD in the young entails that we explore and implement available screening methods for this population, and perform the necessary investigations such as electrocardiography (ECG) and echocardiography. In this review, we not only explore the vast etiology associated with SCD in those age < 35, but emphasize evaluation methods, who is at risk, and delve into screening of SCD in potential victims and their family members, in an attempt to prevent this traumatic event. Future research must work towards establishing preventative measures in order to reduce SCD, particularly unexplained SCD in the young.
心源性猝死(SCD)可影响所有年龄组,包括年轻人。虽然在35岁以下人群中不太常见,但年轻人中SCD的发生引发了关注,其病因多样且往往存在诸多未解之谜。虽然冠状动脉疾病是35岁以上人群SCD的主要原因,但年轻人群面临着与SCD相关的不同病理类型,包括心律失常和心肌病。年轻人SCD的悲剧性质要求我们探索并为该人群实施可用的筛查方法,并进行必要的检查,如心电图(ECG)和超声心动图检查。在本综述中,我们不仅探讨了35岁以下人群中与SCD相关的广泛病因,还强调了评估方法、高危人群,并深入研究对潜在受害者及其家庭成员进行SCD筛查,以试图预防这一创伤性事件。未来的研究必须致力于建立预防措施,以减少SCD,尤其是年轻人中原因不明的SCD。