Zhu Siji, Wang Haoyu, Lin Lin, Fei Xiaochun, Wu Jiayi
Department of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Clinical Laboratory, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Oncol. 2023 Jan 23;12:1013653. doi: 10.3389/fonc.2022.1013653. eCollection 2022.
Primary breast osteosarcoma is a rare subtype of breast malignancy with limited clinical evidence, inadequate biological understanding, and unmet treatment consensus. Here, we report an unusual case of primary breast osteosarcoma developing in the same quadrant of the breast 2 years after initial dissection and radiation of invasive ductal carcinoma. Thorough evaluations of imaging and pathology were conducted while genomic alterations of both primary and secondary tumors, as well as peripheral blood samples, were explored through the next-generation sequencing technique. A comprehensive review of the current literature was also performed on this rare malignancy.
原发性乳腺骨肉瘤是一种罕见的乳腺恶性肿瘤亚型，临床证据有限，生物学认识不足，治疗共识尚未达成。在此，我们报告一例不寻常的原发性乳腺骨肉瘤病例，该病例发生在浸润性导管癌初次切除及放疗2年后的同一乳腺象限。我们进行了全面的影像学和病理学评估，同时通过下一代测序技术探索了原发性和继发性肿瘤以及外周血样本的基因组改变。我们还对这种罕见的恶性肿瘤进行了当前文献的全面综述。
